ENSMUSG00000033088


Mus musculus

Features
Gene ID: ENSMUSG00000033088
  
Biological name :Triobp
  
Synonyms : Q99KW3 / TRIO and F-actin-binding protein / Triobp
  
Possible biological names infered from orthology : Q9H2D6
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E1
Gene start: 78947724
Gene end: 79005869
  
Corresponding Affymetrix probe sets: 10425177 (MoGene1.0st)   1427447_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000155796
Ensembl peptide - ENSMUSP00000155397
Ensembl peptide - ENSMUSP00000155650
Ensembl peptide - ENSMUSP00000105309
Ensembl peptide - ENSMUSP00000105311
Ensembl peptide - ENSMUSP00000105312
Ensembl peptide - ENSMUSP00000116765
Ensembl peptide - ENSMUSP00000122988
NCBI entrez gene - 110253     See in Manteia.
MGI - MGI:1349410
RefSeq - XM_017316365
RefSeq - NM_138579
RefSeq - XM_006520284
RefSeq - XM_006520285
RefSeq - XM_006520286
RefSeq - XM_006520287
RefSeq - XM_006520288
RefSeq - XM_006520289
RefSeq - XM_006520291
RefSeq - NM_001024716
RefSeq - NM_001039155
RefSeq - NM_001039156
RefSeq Peptide - NP_001034245
RefSeq Peptide - NP_613045
RefSeq Peptide - NP_001019887
RefSeq Peptide - NP_001034244
swissprot - Q99KW3
swissprot - G5E8W1
swissprot - J9JI90
swissprot - E9QMQ3
Ensembl - ENSMUSG00000033088
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 triobpaENSDARG00000075870Danio rerio
 triobpbENSDARG00000006385Danio rerio
 ENSGALG00000045591Gallus gallus
 ENSGALG00000034518Gallus gallus
 Q9H2D6ENSG00000100106Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mprip / P97434 / Myosin phosphatase Rho-interacting protein / Q6WCQ1*ENSMUSG0000000541713


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR029908  TRIO and F-actin-binding protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0051017 actin filament bundle assembly IDA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060088 auditory receptor cell stereocilium organization IMP
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0015629 actin cytoskeleton ISO
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0032420 stereocilium IDA
 cellular_componentGO:0032437 cuticular plate IDA
 cellular_componentGO:0120043 stereocilium shaft IDA
 cellular_componentGO:0120044 stereocilium base IDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001967 deafness "inability to hear" [J:57651]
Show

Allelic Composition: Mylk3tm1Jtst/Mylk3+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004432 abnormal cochlear hair cell physiology "anomalies in processes pertinent to the integrated function of cochlear hair cells i.e. the sensory cells in the spiral organ which are in synaptic contact with sensory as well as efferent fibers of the cochlear (auditory) nerve " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mylk3tm1Jtst/Mylk3+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004523 decreased cochlear hair cell stereocilia number "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mylk3tm1Jtst/Mylk3+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004527 abnormal outer hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mylk3tm1Jtst/Mylk3+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004528 fused outer hair cell stereocilia "coalescence of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear outer hair cells, often resulting in giant stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mylk3tm1Jtst/Mylk3+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004532 abnormal inner hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typically linear or U-shaped pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear IHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mylk3tm1Jtst/Mylk3+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004533 fused inner hair cell stereocilia "coalescence of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner hair cells, often resulting in giant stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mylk3tm1Jtst/Mylk3+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004589 abnormal cochlear hair cell development "atypical initial production, differentiation, migration or maturation of the sensory epithelial cells of the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mylk3tm1Jtst/Mylk3+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mylk3tm1Jtst/Mylk3+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: TriobpGt(YHB226)Byg/TriobpGt(YHB226)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Mylk3tm1Jtst/Mylk3+
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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