ENSG00000100577


Homo sapiens

Features
Gene ID: ENSG00000100577
  
Biological name :GSTZ1
  
Synonyms : glutathione S-transferase zeta 1 / GSTZ1 / O43708
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q24.3
Gene start: 77320884
Gene end: 77331597
  
Corresponding Affymetrix probe sets: 209531_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000452346
Ensembl peptide - ENSP00000451976
Ensembl peptide - ENSP00000452498
Ensembl peptide - ENSP00000452531
Ensembl peptide - ENSP00000216465
Ensembl peptide - ENSP00000314404
Ensembl peptide - ENSP00000354959
Ensembl peptide - ENSP00000377335
Ensembl peptide - ENSP00000450487
Ensembl peptide - ENSP00000451150
Ensembl peptide - ENSP00000451850
Ensembl peptide - ENSP00000451927
NCBI entrez gene - 2954     See in Manteia.
OMIM - 603758
RefSeq - XM_017021243
RefSeq - NM_001312660
RefSeq - NM_145870
RefSeq - NM_145871
RefSeq - XM_011536670
RefSeq - XM_011536671
RefSeq Peptide - NP_665877
RefSeq Peptide - NP_665878
RefSeq Peptide - NP_001299589
swissprot - O43708
swissprot - A0A0A0MR33
swissprot - A0A0C4DFM0
swissprot - G3V267
swissprot - G3V3B9
swissprot - G3V4T6
swissprot - G3V5T0
swissprot - G3V5G8
swissprot - G3V5U6
swissprot - H0YJN8
Ensembl - ENSG00000100577
  
Related genetic diseases (OMIM): 617596 - [Maleylacetoacetate isomerase deficiency], 617596
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GSTZ1ENSDARG00000027984Danio rerio
 GSTZ1ENSGALG00000010432Gallus gallus
 Gstz1ENSMUSG00000021033Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004045  Glutathione S-transferase, N-terminal
 IPR004046  Glutathione S-transferase, C-terminal
 IPR005955  Glutathione S-transferases, class Zeta
 IPR010987  Glutathione S-transferase, C-terminal-like
 IPR034330  Glutathione S-transferases, class Zeta , C-terminal
 IPR034333  Glutathione S-transferases, class Zeta , N-terminal
 IPR036249  Thioredoxin-like superfamily
 IPR036282  Glutathione S-transferase, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006559 L-phenylalanine catabolic process TAS
 biological_processGO:0006572 tyrosine catabolic process IEA
 biological_processGO:0006749 glutathione metabolic process IDA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009072 aromatic amino acid family metabolic process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:1901687 glutathione derivative biosynthetic process TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISS
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004364 glutathione transferase activity TAS
 molecular_functionGO:0004602 glutathione peroxidase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016034 maleylacetoacetate isomerase activity EXP
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI


Pathways (from Reactome)
Pathway description
Glutathione conjugation
Regulation of pyruvate dehydrogenase (PDH) complex
Phenylalanine and tyrosine catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100577 GSTZ1 / O43708 / glutathione S-transferase zeta 1  / complex






 

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