ENSG00000100902


Homo sapiens

Features
Gene ID: ENSG00000100902
  
Biological name :PSMA6
  
Synonyms : P60900 / proteasome subunit alpha 6 / PSMA6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q13.2
Gene start: 35278633
Gene end: 35317493
  
Corresponding Affymetrix probe sets: 208805_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000485776
Ensembl peptide - ENSP00000479620
Ensembl peptide - ENSP00000485817
Ensembl peptide - ENSP00000261479
Ensembl peptide - ENSP00000444844
Ensembl peptide - ENSP00000450528
Ensembl peptide - ENSP00000450844
Ensembl peptide - ENSP00000451171
Ensembl peptide - ENSP00000451254
Ensembl peptide - ENSP00000451432
Ensembl peptide - ENSP00000451958
Ensembl peptide - ENSP00000452566
Ensembl peptide - ENSP00000452603
NCBI entrez gene - 5687     See in Manteia.
OMIM - 602855
RefSeq - XM_017021468
RefSeq - NM_001282232
RefSeq - NM_001282233
RefSeq - NM_001282234
RefSeq - NM_002791
RefSeq Peptide - NP_001269163
RefSeq Peptide - NP_002782
RefSeq Peptide - NP_001269161
RefSeq Peptide - NP_001269162
swissprot - A0A140VK44
swissprot - G3V295
swissprot - G3V2S7
swissprot - G3V3I1
swissprot - G3V4S5
swissprot - G3V3U4
swissprot - G3V5Z7
swissprot - H0YJC4
swissprot - P60900
Ensembl - ENSG00000100902
  
Related genetic diseases (OMIM): 608446 - {Myocardial infarction, susceptibility to}, 608446
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psma6aENSDARG00000019398Danio rerio
 psma6bENSDARG00000013966Danio rerio
 PSMA6ENSGALG00000010060Gallus gallus
 Psma6ENSMUSG00000021024Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000426  Proteasome alpha-subunit, N-terminal domain
 IPR001353  Proteasome, subunit alpha/beta
 IPR023332  Proteasome alpha-type subunit
 IPR029055  Nucleophile aminohydrolases, N-terminal
 IPR034642  Proteasome subunit alpha6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006521 regulation of cellular amino acid metabolic process TAS
 biological_processGO:0010972 negative regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process TAS
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0038061 NIK/NF-kappaB signaling TAS
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0043488 regulation of mRNA stability TAS
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0050727 regulation of inflammatory response IC
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0051436 obsolete negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0051437 obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IEA
 biological_processGO:0055085 transmembrane transport TAS
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway TAS
 biological_processGO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway TAS
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway TAS
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation TAS
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0000932 P-body ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005839 proteasome core complex IEA
 cellular_componentGO:0005844 polysome IDA
 cellular_componentGO:0016363 nuclear matrix ISS
 cellular_componentGO:0019773 proteasome core complex, alpha-subunit complex IEA
 cellular_componentGO:0030016 myofibril ISS
 cellular_componentGO:0030017 sarcomere ISS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003723 RNA binding IDA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004298 threonine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0035639 purine ribonucleoside triphosphate binding NAS
 molecular_functionGO:0051059 NF-kappaB binding IPI


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants that dont undergo autocatalytic processing are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr