ENSMUSG00000021024


Mus musculus

Features
Gene ID: ENSMUSG00000021024
  
Biological name :Psma6
  
Synonyms : Proteasome subunit alpha type-6 / Psma6 / Q9QUM9
  
Possible biological names infered from orthology : P60900 / proteasome subunit alpha 6
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: C1
Gene start: 55384222
Gene end: 55418454
  
Corresponding Affymetrix probe sets: 10395816 (MoGene1.0st)   1416506_at (Mouse Genome 430 2.0 Array)   1435316_at (Mouse Genome 430 2.0 Array)   1435317_x_at (Mouse Genome 430 2.0 Array)   1437144_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123914
Ensembl peptide - ENSMUSP00000124781
Ensembl peptide - ENSMUSP00000021412
NCBI entrez gene - 26443     See in Manteia.
MGI - MGI:1347006
RefSeq - NM_011968
RefSeq - NM_001310583
RefSeq Peptide - NP_001297512
RefSeq Peptide - NP_036098
swissprot - Q9QUM9
swissprot - E0CYT2
swissprot - E0CXB1
Ensembl - ENSMUSG00000021024
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psma6aENSDARG00000019398Danio rerio
 psma6bENSDARG00000013966Danio rerio
 PSMA6ENSGALG00000010060Gallus gallus
 PSMA6ENSG00000100902Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000426  Proteasome alpha-subunit, N-terminal domain
 IPR001353  Proteasome, subunit alpha/beta
 IPR023332  Proteasome alpha-type subunit
 IPR029055  Nucleophile aminohydrolases, N-terminal
 IPR034642  Proteasome subunit alpha6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007519 skeletal muscle tissue development NAS
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process ISS
 cellular_componentGO:0000502 proteasome complex ISO
 cellular_componentGO:0000932 P-body IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005839 proteasome core complex IDA
 cellular_componentGO:0005844 polysome IEA
 cellular_componentGO:0016363 nuclear matrix IDA
 cellular_componentGO:0019773 proteasome core complex, alpha-subunit complex IEA
 cellular_componentGO:0030016 myofibril IEA
 cellular_componentGO:0030017 sarcomere IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004298 threonine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0051059 NF-kappaB binding IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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