ENSG00000101082


Homo sapiens

Features
Gene ID: ENSG00000101082
  
Biological name :SLA2
  
Synonyms : Q9H6Q3 / SLA2 / Src like adaptor 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: q11.23
Gene start: 36612318
Gene end: 36646216
  
Corresponding Affymetrix probe sets: 1555688_s_at (Human Genome U133 Plus 2.0 Array)   232234_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262866
Ensembl peptide - ENSP00000353890
NCBI entrez gene - 84174     See in Manteia.
OMIM - 606577
RefSeq - XM_017028098
RefSeq - NM_032214
RefSeq - NM_175077
RefSeq Peptide - NP_778252
RefSeq Peptide - NP_115590
swissprot - Q9H6Q3
Ensembl - ENSG00000101082
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-25d12.7ENSDARG00000099887Danio rerio
 sla2ENSDARG00000020788Danio rerio
 SLA2ENSGALG00000025948Gallus gallus
 Sla2ENSMUSG00000027636Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SLA / Q13239 / Src like adaptorENSG0000015592639


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001452  SH3 domain
 IPR035052  SLAP, SH2 domain
 IPR035054  Src-like-adapter 2
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0019724 B cell mediated immunity TAS
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030522 intracellular receptor signaling pathway TAS
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042110 T cell activation TAS
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0050776 regulation of immune response NAS
 biological_processGO:0050849 negative regulation of calcium-mediated signaling IDA
 biological_processGO:0050851 antigen receptor-mediated signaling pathway TAS
 biological_processGO:0050869 negative regulation of B cell activation TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0010008 endosome membrane NAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IDA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0047485 protein N-terminus binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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