ENSMUSG00000027636


Mus musculus

Features
Gene ID: ENSMUSG00000027636
  
Biological name :Sla2
  
Synonyms : Q8R4L0 / Sla2 / Src-like-adapter 2
  
Possible biological names infered from orthology : Q9H6Q3 / Src like adaptor 2
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H1
Gene start: 156872457
Gene end: 156887192
  
Corresponding Affymetrix probe sets: 10489055 (MoGene1.0st)   1437504_at (Mouse Genome 430 2.0 Array)   1451492_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029164
Ensembl peptide - ENSMUSP00000105189
NCBI entrez gene - 77799     See in Manteia.
MGI - MGI:1925049
RefSeq - XM_011239846
RefSeq - NM_029983
RefSeq - XM_006500405
RefSeq - XM_011239845
RefSeq Peptide - NP_001343424
RefSeq Peptide - NP_084259
swissprot - Q8R4L0
Ensembl - ENSMUSG00000027636
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-25d12.7ENSDARG00000099887Danio rerio
 sla2ENSDARG00000020788Danio rerio
 SLA2ENSGALG00000025948Gallus gallus
 SLA2ENSG00000101082Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sla / Q60898 / src-like adaptor / Q13239*ENSMUSG0000002237241


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001452  SH3 domain
 IPR035052  SLAP, SH2 domain
 IPR035054  Src-like-adapter 2
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042110 T cell activation IDA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0050849 negative regulation of calcium-mediated signaling ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity ISS
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0047485 protein N-terminus binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Gnao1tm4Lbi/Gnao1tm4Lbi,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008115 abnormal dendritic cell differentiation "atypical production of or inability to produce a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnao1tm4Lbi/Gnao1tm4Lbi,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Gnao1tm4Lbi/Gnao1tm4Lbi,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Gnao1tm4Lbi/Gnao1tm4Lbi,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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