ENSMUSG00000022372


Mus musculus

Features
Gene ID: ENSMUSG00000022372
  
Biological name :Sla
  
Synonyms : Q60898 / Sla / src-like adaptor
  
Possible biological names infered from orthology : Q13239
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D2
Gene start: 66780819
Gene end: 66831829
  
Corresponding Affymetrix probe sets: 10429128 (MoGene1.0st)   1420818_at (Mouse Genome 430 2.0 Array)   1420819_at (Mouse Genome 430 2.0 Array)   1441761_at (Mouse Genome 430 2.0 Array)   1447813_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000098138
Ensembl peptide - ENSMUSP00000127901
Ensembl peptide - ENSMUSP00000130222
Ensembl peptide - ENSMUSP00000131865
NCBI entrez gene - 20491     See in Manteia.
MGI - MGI:104295
RefSeq - XM_017316522
RefSeq - NM_001029841
RefSeq - NM_009192
RefSeq - XM_006520668
RefSeq - XM_011245530
RefSeq Peptide - NP_001025012
RefSeq Peptide - NP_033218
swissprot - Q4FJX0
swissprot - Q60898
swissprot - A0A0R4J247
Ensembl - ENSMUSG00000022372
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sla1ENSDARG00000054340Danio rerio
 SLA (1 of many)ENSDARG00000100287Danio rerio
 SLAENSGALG00000039264Gallus gallus
 SLAENSG00000155926Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sla2 / Q8R4L0 / Src-like-adapter 2 / Q9H6Q3* / Src like adaptor 2*ENSMUSG0000002763636


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001452  SH3 domain
 IPR035052  SLAP, SH2 domain
 IPR035055  Src-like-adapter
 IPR035596  Src-like-adapter, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc9a3r1tm1Ssl/Slc9a3r1tm1Ssl
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Slatm1Weis/Slatm1Weis,Zap70tm1Weis/Zap70tm1Weis
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Gnao1tm4Lbi/Gnao1tm4Lbi,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002408 abnormal double-positive T cell "anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc9a3r1tm1Ssl/Slc9a3r1tm1Ssl
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
Show

Allelic Composition: Slc9a3r1tm1Ssl/Slc9a3r1tm1Ssl
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slatm1Weis/Slatm1Weis,Zap70tm1Weis/Zap70tm1Weis
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0008115 abnormal dendritic cell differentiation "atypical production of or inability to produce a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnao1tm4Lbi/Gnao1tm4Lbi,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Gnao1tm4Lbi/Gnao1tm4Lbi,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Gnao1tm4Lbi/Gnao1tm4Lbi,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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