ENSG00000101557


Homo sapiens

Features
Gene ID: ENSG00000101557
  
Biological name :USP14
  
Synonyms : P54578 / ubiquitin specific peptidase 14 / USP14
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: 1
Band: p11.32
Gene start: 158383
Gene end: 214629
  
Corresponding Affymetrix probe sets: 201671_x_at (Human Genome U133 Plus 2.0 Array)   201672_s_at (Human Genome U133 Plus 2.0 Array)   226567_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000463891
Ensembl peptide - ENSP00000464447
Ensembl peptide - ENSP00000473563
Ensembl peptide - ENSP00000261601
Ensembl peptide - ENSP00000373083
Ensembl peptide - ENSP00000383125
Ensembl peptide - ENSP00000462315
NCBI entrez gene - 9097     See in Manteia.
OMIM - 607274
RefSeq - NM_001037334
RefSeq - NM_005151
RefSeq Peptide - NP_001032411
RefSeq Peptide - NP_005142
swissprot - A6NJA2
swissprot - R4GNB0
swissprot - J3KS55
swissprot - J3QQT6
swissprot - P54578
Ensembl - ENSG00000101557
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp14ENSDARG00000025889Danio rerio
 USP14ENSGALG00000014920Gallus gallus
 Usp14ENSMUSG00000047879Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR018200  Ubiquitin specific protease, conserved site
 IPR019954  Ubiquitin conserved site
 IPR028889  Ubiquitin specific protease domain
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0016579 protein deubiquitination IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050920 regulation of chemotaxis IMP
 biological_processGO:0061136 regulation of proteasomal protein catabolic process IMP
 biological_processGO:0099116 tRNA 5"-end processing IEA
 biological_processGO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process IMP
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity TAS
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity TAS
 molecular_functionGO:0004866 endopeptidase inhibitor activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008193 tRNA guanylyltransferase activity TAS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IDA
 molecular_functionGO:0070628 proteasome binding IDA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000130706 ADRM1 / Q16186 / adhesion regulating molecule 1  / reaction / complex






 

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