ENSG00000102158


Homo sapiens

Features
Gene ID: ENSG00000102158
  
Biological name :MAGT1
  
Synonyms : magnesium transporter 1 / MAGT1 / Q9H0U3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: q21.1
Gene start: 77826364
Gene end: 77895593
  
Corresponding Affymetrix probe sets: 210596_at (Human Genome U133 Plus 2.0 Array)   221553_at (Human Genome U133 Plus 2.0 Array)   224899_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000478379
Ensembl peptide - ENSP00000480732
Ensembl peptide - ENSP00000354649
Ensembl peptide - ENSP00000362433
NCBI entrez gene - 84061     See in Manteia.
OMIM - 300715
RefSeq - NM_032121
RefSeq Peptide - NP_115497
swissprot - A0A087WU53
swissprot - Q9H0U3
Ensembl - ENSG00000102158
  
Related genetic diseases (OMIM): 300853 - Immunodeficiency, X-linked, with magnesium defect, Epstein-Barr virus infection and neoplasia, 300853
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 magt1ENSDARG00000058062Danio rerio
 MAGT1ENSGALG00000007861Gallus gallus
 Magt1ENSMUSG00000031232Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TUSC3 / Q13454 / tumor suppressor candidate 3ENSG0000010472360


Protein motifs (from Interpro)
Interpro ID Name
 IPR006844  Magnesium transporter protein 1
 IPR021149  Oligosaccharyl transferase complex, subunit OST3/OST6
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006487 protein N-linked glycosylation NAS
 biological_processGO:0015693 magnesium ion transport IMP
 biological_processGO:0018279 protein N-linked glycosylation via asparagine TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0050890 cognition IMP
 biological_processGO:0055085 transmembrane transport TAS
 biological_processGO:1903830 magnesium ion transmembrane transport IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0008250 oligosaccharyltransferase complex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0035577 azurophil granule membrane TAS
 molecular_functionGO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015095 magnesium ion transmembrane transporter activity TAS


Pathways (from Reactome)
Pathway description
Asparagine N-linked glycosylation
Miscellaneous transport and binding events
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0001417 X-linked inheritance "A mode of inheritance that is observed for traits related to a gene encoded on the X chromosome." [HPO:curators]
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 HP:0002665 Lymphoma "A cancer originating in lymphocytes and presenting as a solid tumor of lymhpoid cells." [HPO:curators]
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 HP:0002721 Immunodeficiency 
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 HP:0004429 Recurrent viral infections 
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 HP:0005407 Decreased number of CD4+ T cells 
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 HP:0005419 Decreased T cell activation 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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