ENSG00000102760


Homo sapiens

Features
Gene ID: ENSG00000102760
  
Biological name :RGCC
  
Synonyms : Q9H4X1 / regulator of cell cycle / RGCC
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: 1
Band: q14.11
Gene start: 41457559
Gene end: 41470882
  
Corresponding Affymetrix probe sets: 218723_s_at (Human Genome U133 Plus 2.0 Array)   228193_s_at (Human Genome U133 Plus 2.0 Array)   239827_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000368664
NCBI entrez gene - 28984     See in Manteia.
OMIM - 610077
RefSeq - NM_014059
RefSeq Peptide - NP_054778
swissprot - Q9H4X1
Ensembl - ENSG00000102760
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rgccENSDARG00000035810Danio rerio
 RGCCENSGALG00000016954Gallus gallus
 RgccENSMUSG00000022018Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR029252  Regulator of cell cycle RGCC


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001100 negative regulation of exit from mitosis IDA
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IDA
 biological_processGO:0003331 positive regulation of extracellular matrix constituent secretion IDA
 biological_processGO:0006956 complement activation IMP
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0016525 negative regulation of angiogenesis IDA
 biological_processGO:0031659 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle IDA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IDA
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration IDA
 biological_processGO:0045840 positive regulation of mitotic nuclear division IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0050710 negative regulation of cytokine secretion IMP
 biological_processGO:0050715 positive regulation of cytokine secretion IMP
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0051496 positive regulation of stress fiber assembly IDA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0071158 positive regulation of cell cycle arrest IDA
 biological_processGO:0071456 cellular response to hypoxia IMP
 biological_processGO:0071850 mitotic cell cycle arrest IDA
 biological_processGO:0072537 fibroblast activation IEA
 biological_processGO:0090272 negative regulation of fibroblast growth factor production IDA
 biological_processGO:1901203 positive regulation of extracellular matrix assembly IDA
 biological_processGO:1901991 negative regulation of mitotic cell cycle phase transition IDA
 biological_processGO:2000048 negative regulation of cell-cell adhesion mediated by cadherin IDA
 biological_processGO:2000353 positive regulation of endothelial cell apoptotic process IDA
 biological_processGO:2000573 positive regulation of DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030295 protein kinase activator activity IDA
 molecular_functionGO:0070412 R-SMAD binding IPI


Pathways (from Reactome)
Pathway description
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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