ENSMUSG00000022018


Mus musculus

Features
Gene ID: ENSMUSG00000022018
  
Biological name :Rgcc
  
Synonyms : Q9DBX1 / Regulator of cell cycle RGCC / Rgcc
  
Possible biological names infered from orthology : Q9H4X1 / regulator of cell cycle
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D3
Gene start: 79288756
Gene end: 79301645
  
Corresponding Affymetrix probe sets: 10421810 (MoGene1.0st)   1418003_at (Mouse Genome 430 2.0 Array)   1438511_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022595
NCBI entrez gene - 66214     See in Manteia.
MGI - MGI:1913464
RefSeq - NM_025427
RefSeq Peptide - NP_079703
swissprot - Q9DBX1
Ensembl - ENSMUSG00000022018
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rgccENSDARG00000035810Danio rerio
 RGCCENSGALG00000016954Gallus gallus
 RGCCENSG00000102760Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR029252  Regulator of cell cycle RGCC


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle ISO
 biological_processGO:0001100 negative regulation of exit from mitosis IEA
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IEA
 biological_processGO:0003331 positive regulation of extracellular matrix constituent secretion IEA
 biological_processGO:0006956 complement activation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0031659 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IEA
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045840 positive regulation of mitotic nuclear division IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050710 negative regulation of cytokine secretion IEA
 biological_processGO:0050715 positive regulation of cytokine secretion IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0071158 positive regulation of cell cycle arrest IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071850 mitotic cell cycle arrest IEA
 biological_processGO:0072537 fibroblast activation IMP
 biological_processGO:0090272 negative regulation of fibroblast growth factor production IEA
 biological_processGO:1901203 positive regulation of extracellular matrix assembly IEA
 biological_processGO:1901991 negative regulation of mitotic cell cycle phase transition IEA
 biological_processGO:2000048 negative regulation of cell-cell adhesion mediated by cadherin IEA
 biological_processGO:2000353 positive regulation of endothelial cell apoptotic process IEA
 biological_processGO:2000573 positive regulation of DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030295 protein kinase activator activity IEA
 molecular_functionGO:0070412 R-SMAD binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ildr1Gt(D178D03)Wrst/Ildr1Gt(D178D03)Wrst
Genetic Background: involves: 129S2/SvPas * Swiss Webster

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Ildr1Gt(D178D03)Wrst/Ildr1Gt(D178D03)Wrst
Genetic Background: involves: 129S2/SvPas * Swiss Webster

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ildr1Gt(D178D03)Wrst/Ildr1Gt(D178D03)Wrst
Genetic Background: involves: 129S2/SvPas * Swiss Webster

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ildr1Gt(D178D03)Wrst/Ildr1Gt(D178D03)Wrst
Genetic Background: involves: 129S2/SvPas * Swiss Webster

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ildr1Gt(D178D03)Wrst/Ildr1Gt(D178D03)Wrst
Genetic Background: involves: 129S2/SvPas * Swiss Webster

 MP:0004921 decreased placenta weight "reduction in the weight of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ildr1Gt(D178D03)Wrst/Ildr1Gt(D178D03)Wrst
Genetic Background: involves: 129S2/SvPas * Swiss Webster

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ildr1Gt(D178D03)Wrst/Ildr1Gt(D178D03)Wrst
Genetic Background: involves: 129S2/SvPas * Swiss Webster

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ildr1Gt(D178D03)Wrst/Ildr1Gt(D178D03)Wrst
Genetic Background: involves: 129S2/SvPas * Swiss Webster

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Ildr1Gt(D178D03)Wrst/Ildr1Gt(D178D03)Wrst
Genetic Background: involves: 129S2/SvPas * Swiss Webster

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ildr1Gt(D178D03)Wrst/Ildr1Gt(D178D03)Wrst
Genetic Background: involves: 129S2/SvPas * Swiss Webster

 MP:0011521 decreased placental labyrinth size "reduction in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
Show

Allelic Composition: Ildr1Gt(D178D03)Wrst/Ildr1Gt(D178D03)Wrst
Genetic Background: involves: 129S2/SvPas * Swiss Webster

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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