ENSG00000103152


Homo sapiens

Features
Gene ID: ENSG00000103152
  
Biological name :MPG
  
Synonyms : MPG / N-methylpurine DNA glycosylase / P29372
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p13.3
Gene start: 77007
Gene end: 85853
  
Corresponding Affymetrix probe sets: 203686_at (Human Genome U133 Plus 2.0 Array)   229122_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000388097
Ensembl peptide - ENSP00000219431
Ensembl peptide - ENSP00000348809
Ensembl peptide - ENSP00000380918
NCBI entrez gene - 4350     See in Manteia.
OMIM - 156565
RefSeq - NM_001015052
RefSeq - NM_001015054
RefSeq - NM_002434
RefSeq Peptide - NP_001015052
RefSeq Peptide - NP_001015054
RefSeq Peptide - NP_002425
swissprot - Q1W6H1
swissprot - A2IDA3
swissprot - P29372
Ensembl - ENSG00000103152
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mpgENSDARG00000069729Danio rerio
 MPGENSGALG00000028691Gallus gallus
 MpgENSMUSG00000020287Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003180  Methylpurine-DNA glycosylase
 IPR011034  Formyl transferase-like, C-terminal domain superfamily
 IPR036995  Methylpurine-DNA glycosylase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair TAS
 biological_processGO:0006307 DNA dealkylation involved in DNA repair TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0045007 depurination TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042645 mitochondrial nucleoid IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding TAS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003905 alkylbase DNA N-glycosylase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008725 DNA-3-methyladenine glycosylase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019104 DNA N-glycosylase activity TAS
 molecular_functionGO:0043916 DNA-7-methylguanine glycosylase activity IEA
 molecular_functionGO:0052821 DNA-7-methyladenine glycosylase activity IEA
 molecular_functionGO:0052822 DNA-3-methylguanine glycosylase activity IEA


Pathways (from Reactome)
Pathway description
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Displacement of DNA glycosylase by APEX1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100823 APEX1 / P27695 / apurinic/apyrimidinic endodeoxyribonuclease 1  / reaction






 

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