ENSMUSG00000020287


Mus musculus

Features
Gene ID: ENSMUSG00000020287
  
Biological name :Mpg
  
Synonyms : Mpg / N-methylpurine-DNA glycosylase / Q04841
  
Possible biological names infered from orthology : P29372
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A4
Gene start: 32226505
Gene end: 32232700
  
Corresponding Affymetrix probe sets: 10375038 (MoGene1.0st)   1417571_at (Mouse Genome 430 2.0 Array)   1417572_at (Mouse Genome 430 2.0 Array)   1442302_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121960
Ensembl peptide - ENSMUSP00000118208
Ensembl peptide - ENSMUSP00000020528
NCBI entrez gene - 268395     See in Manteia.
MGI - MGI:97073
RefSeq - NM_010822
RefSeq Peptide - NP_034952
swissprot - Q04841
swissprot - F2Z3Y1
Ensembl - ENSMUSG00000020287
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mpgENSDARG00000069729Danio rerio
 MPGENSGALG00000028691Gallus gallus
 MPGENSG00000103152Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003180  Methylpurine-DNA glycosylase
 IPR011034  Formyl transferase-like, C-terminal domain superfamily
 IPR036995  Methylpurine-DNA glycosylase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0042645 mitochondrial nucleoid IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003905 alkylbase DNA N-glycosylase activity IMP
 molecular_functionGO:0008725 DNA-3-methyladenine glycosylase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043916 DNA-7-methylguanine glycosylase activity IEA
 molecular_functionGO:0052821 DNA-7-methyladenine glycosylase activity IEA
 molecular_functionGO:0052822 DNA-3-methylguanine glycosylase activity IEA


Pathways (from Reactome)
Pathway description
Cleavage of the damaged purine
Displacement of DNA glycosylase by APEX1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Izumo1rtm2a(KOMP)Wtsi/Izumo1rtm2a(KOMP)Wtsi
Genetic Background: C57BL/6N-Izumo1rtm2a(KOMP)Wtsi/Wtsi

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mpgtm1Rhe/Mpgtm1Rhe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mpgtm1Rhe/Mpgtm1Rhe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0005334 abnormal fat pad "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx2-5tm1(cre)Rjs/Nkx2-5+,Nsd2tm1Ykan/Nsd2+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Mpgtm1Rhe/Mpgtm1Rhe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0008034 enhanced lipolysis "increase in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mpgtm1Rhe/Mpgtm1Rhe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mpgtm1Rhe/Mpgtm1Rhe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mpgtm1Rhe/Mpgtm1Rhe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mpgtm1Rhe/Mpgtm1Rhe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Mpgtm1Rhe/Mpgtm1Rhe
Genetic Background: B6.129P2-Mpgtm1Rhe

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0009488 pancreatic islet cell apoptosis "change in the timing or the number of pancreatic islet cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mpgtm1Rhe/Mpgtm1Rhe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000035960 Apex1 / P28352 / DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) lyase, mitochondrial / P27695* / apurinic/apyrimidinic endodeoxyribonuclease 1*  / reaction






 

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