ENSG00000104518


Homo sapiens

Features
Gene ID: ENSG00000104518
  
Biological name :GSDMD
  
Synonyms : gasdermin D / GSDMD / P57764
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q24.3
Gene start: 143553207
Gene end: 143563062
  
Corresponding Affymetrix probe sets: 218154_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000433209
Ensembl peptide - ENSP00000433263
Ensembl peptide - ENSP00000437065
Ensembl peptide - ENSP00000436684
Ensembl peptide - ENSP00000434452
Ensembl peptide - ENSP00000434386
Ensembl peptide - ENSP00000433958
Ensembl peptide - ENSP00000262580
Ensembl peptide - ENSP00000432351
NCBI entrez gene - 79792     See in Manteia.
OMIM - 617042
RefSeq - NM_024736
RefSeq - NM_001166237
RefSeq - XM_011517301
RefSeq Peptide - NP_001159709
RefSeq Peptide - NP_079012
swissprot - G3V1A6
swissprot - E9PRF1
swissprot - P57764
swissprot - H0YDB0
swissprot - E9PQR9
swissprot - E9PQ48
swissprot - E9PNZ0
swissprot - E9PIB2
Ensembl - ENSG00000104518
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GSDMAENSGALG00000013495Gallus gallus
 GsdmdENSMUSG00000022575Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GSDMA / Q96QA5 / gasdermin AENSG0000016791430
GSDMC / Q9BYG8 / gasdermin CENSG0000014769728
GSDMB / Q8TAX9 / gasdermin BENSG0000007360523


Protein motifs (from Interpro)
Interpro ID Name
 IPR007677  Gasdermin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0012501 programmed cell death IEA
 biological_processGO:0019835 cytolysis ISS
 biological_processGO:0031668 cellular response to extracellular stimulus IEA
 biological_processGO:0035915 pore formation in membrane of other organism ISS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0046931 pore complex assembly ISS
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion ISS
 biological_processGO:0050829 defense response to Gram-negative bacterium ISS
 biological_processGO:0050830 defense response to Gram-positive bacterium ISS
 biological_processGO:0051260 protein homooligomerization ISS
 biological_processGO:0070269 pyroptosis ISS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0035580 specific granule lumen TAS
 cellular_componentGO:0061702 inflammasome complex IEA
 cellular_componentGO:0072559 NLRP3 inflammasome complex ISS
 cellular_componentGO:1904724 tertiary granule lumen TAS
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0001786 phosphatidylserine binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding ISS
 molecular_functionGO:0070273 phosphatidylinositol-4-phosphate binding ISS
 molecular_functionGO:0070300 phosphatidic acid binding ISS
 molecular_functionGO:1901612 cardiolipin binding ISS


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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