ENSMUSG00000022575


Mus musculus

Features
Gene ID: ENSMUSG00000022575
  
Biological name :Gsdmd
  
Synonyms : Gasdermin-D Gasdermin-D, N-terminal Gasdermin-D, C-terminal / Gsdmd / Q9D8T2
  
Possible biological names infered from orthology : gasdermin D / P57764
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: D3
Gene start: 75862327
Gene end: 75867408
  
Corresponding Affymetrix probe sets: 10424731 (MoGene1.0st)   1428767_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023238
Ensembl peptide - ENSMUSP00000155766
Ensembl peptide - ENSMUSP00000155802
NCBI entrez gene - 69146     See in Manteia.
MGI - MGI:1916396
RefSeq - XM_006521343
RefSeq - NM_026960
RefSeq - XM_006521342
RefSeq Peptide - NP_081236
swissprot - Q9D8T2
Ensembl - ENSMUSG00000022575
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GSDMAENSGALG00000013495Gallus gallus
 GSDMDENSG00000104518Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gsdma / Q9EST1 / Gasdermin-A / Q96QA5*ENSMUSG0000001720430
Gsdma2 / Q32M21 / Gasdermin-A2 / GSDMA* / Q96QA5* / gasdermin A*ENSMUSG0000001721129
Gsdma3 / Q5Y4Y6 / Gasdermin-A3 / GSDMA* / Q96QA5* / gasdermin A*ENSMUSG0000006422428
Gsdmc2 / Q2KHK6 / Gasdermin-C2 / GSDMC* / Q9BYG8* / gasdermin C*ENSMUSG0000005629327
Gsdmc3 / Q8CB12 / Gasdermin-C3 / GSDMC* / Q9BYG8* / gasdermin C*ENSMUSG0000005582727
Gsdmc4 / Q3TR54 / Gasdermin-C4 / GSDMC* / Q9BYG8* / gasdermin C*ENSMUSG0000005574826
Gsdmc / Q99NB5 / Gasdermin-C / Q9BYG8*ENSMUSG0000007902525


Protein motifs (from Interpro)
Interpro ID Name
 IPR007677  Gasdermin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0012501 programmed cell death IEA
 biological_processGO:0019835 cytolysis IDA
 biological_processGO:0031668 cellular response to extracellular stimulus IDA
 biological_processGO:0035915 pore formation in membrane of other organism IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0046931 pore complex assembly IDA
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IDA
 biological_processGO:0050829 defense response to Gram-negative bacterium IDA
 biological_processGO:0050830 defense response to Gram-positive bacterium IDA
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0070269 pyroptosis IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0061702 inflammasome complex IEA
 cellular_componentGO:0072559 NLRP3 inflammasome complex IDA
 molecular_functionGO:0001786 phosphatidylserine binding IDA
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA
 molecular_functionGO:0070273 phosphatidylinositol-4-phosphate binding IDA
 molecular_functionGO:0070300 phosphatidic acid binding IDA
 molecular_functionGO:1901612 cardiolipin binding IDA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pkhd1tm1Cjwa/Pkhd1tm1Cjwa
Genetic Background: B6.129S6-Pkhd1tm1Cjwa

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adipoqtm1Pesch/Adipoqtm1Pesch
Genetic Background: B6.129S7-Adipoqtm1Pesch

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Shank3tm5.1Gfng/Shank3tm5.1Gfng,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Gsdmdem3Fcw/Gsdmdem3Fcw
Genetic Background: involves: C57BL/6

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adipoqtm1Pesch/Adipoqtm1Pesch
Genetic Background: B6.129S7-Adipoqtm1Pesch

 MP:0011073 abnormal macrophage apoptosis "excessive or absent cell death in macrophages" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Shank3tm5.1Gfng/Shank3tm5.1Gfng,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Gsdmdem3Fcw/Gsdmdem3Fcw
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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