ENSG00000104549


Homo sapiens

Features
Gene ID: ENSG00000104549
  
Biological name :SQLE
  
Synonyms : Q14534 / SQLE / squalene epoxidase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q24.13
Gene start: 124998497
Gene end: 125022283
  
Corresponding Affymetrix probe sets: 1557352_at (Human Genome U133 Plus 2.0 Array)   209218_at (Human Genome U133 Plus 2.0 Array)   213562_s_at (Human Genome U133 Plus 2.0 Array)   213577_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428239
Ensembl peptide - ENSP00000430331
Ensembl peptide - ENSP00000429916
Ensembl peptide - ENSP00000265896
NCBI entrez gene - 6713     See in Manteia.
OMIM - 602019
RefSeq - NM_003129
RefSeq - XM_011517246
RefSeq Peptide - NP_003120
swissprot - H0YBN7
swissprot - E7EVQ6
swissprot - Q14534
swissprot - Q9UNR6
swissprot - E5RJH9
Ensembl - ENSG00000104549
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sqleaENSDARG00000079946Danio rerio
 SQLEENSGALG00000036915Gallus gallus
 SqleENSMUSG00000022351Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002938  FAD-binding domain
 IPR013698  Squalene epoxidase
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006695 cholesterol biosynthetic process TAS
 biological_processGO:0006725 cellular aromatic compound metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0016126 sterol biosynthetic process IBA
 biological_processGO:0045540 regulation of cholesterol biosynthetic process TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004506 squalene monooxygenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA
 molecular_functionGO:0071949 FAD binding IEA


Pathways (from Reactome)
Pathway description
Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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