ENSG00000104885


Homo sapiens

Features
Gene ID: ENSG00000104885
  
Biological name :DOT1L
  
Synonyms : DOT1L / DOT1 like histone lysine methyltransferase / Q8TEK3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.3
Gene start: 2164149
Gene end: 2232578
  
Corresponding Affymetrix probe sets: 214865_at (Human Genome U133 Plus 2.0 Array)   226201_at (Human Genome U133 Plus 2.0 Array)   231297_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000412916
Ensembl peptide - ENSP00000407411
Ensembl peptide - ENSP00000476469
Ensembl peptide - ENSP00000484015
Ensembl peptide - ENSP00000381657
Ensembl peptide - ENSP00000404284
NCBI entrez gene - 84444     See in Manteia.
OMIM - 607375
RefSeq - XM_017027366
RefSeq - NM_032482
RefSeq - XM_005259659
RefSeq - XM_005259660
RefSeq - XM_011528359
RefSeq - XM_011528360
RefSeq - XM_011528361
RefSeq Peptide - NP_115871
swissprot - C9JH95
swissprot - H7C2S2
swissprot - V9GY76
swissprot - A0A087X1A7
swissprot - Q8TEK3
swissprot - H7C3N3
Ensembl - ENSG00000104885
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dot1lENSDARG00000061992Danio rerio
 DOT1LENSGALG00000000843Gallus gallus
 Dot1lENSMUSG00000061589Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR021169  Histone H3-K79 methyltransferase, metazoa
 IPR025789  Histone-lysine N-methyltransferase DOT1 domain
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase
 IPR030445  Histone H3-K79 methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IBA
 biological_processGO:0006281 DNA repair IBA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006342 chromatin silencing IEA
 biological_processGO:0006348 chromatin silencing at telomere IBA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0032200 telomere organization TAS
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034729 histone H3-K79 methylation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046425 regulation of JAK-STAT cascade IDA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:2000677 regulation of transcription regulatory region DNA binding IMP
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0031151 histone methyltransferase activity (H3-K79 specific) IEA
 molecular_functionGO:0042054 histone methyltransferase activity IEA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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