ENSMUSG00000061589


Mus musculus

Features
Gene ID: ENSMUSG00000061589
  
Biological name :Dot1l
  
Synonyms : Dot1l / DOT1 like histone lysine methyltransferase
  
Possible biological names infered from orthology : Q8TEK3
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 80755206
Gene end: 80795461
  
Corresponding Affymetrix probe sets: 10364856 (MoGene1.0st)   10364888 (MoGene1.0st)   1439488_at (Mouse Genome 430 2.0 Array)   1457268_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130408
Ensembl peptide - ENSMUSP00000100973
Ensembl peptide - ENSMUSP00000116581
Ensembl peptide - ENSMUSP00000119492
Ensembl peptide - ENSMUSP00000127762
NCBI entrez gene - 208266     See in Manteia.
MGI - MGI:2143886
RefSeq - XM_006513429
RefSeq - XM_006513431
RefSeq - XM_006513432
RefSeq - XM_011243390
RefSeq - XM_011243391
RefSeq - XM_006513430
RefSeq - NM_199322
RefSeq Peptide - NP_955354
swissprot - Q6XZL8
swissprot - F6SJX8
swissprot - F7CVL0
swissprot - E9Q6I8
swissprot - F6S070
Ensembl - ENSMUSG00000061589
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dot1lENSDARG00000061992Danio rerio
 DOT1LENSGALG00000000843Gallus gallus
 DOT1LENSG00000104885Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR021169  Histone H3-K79 methyltransferase, metazoa
 IPR025789  Histone-lysine N-methyltransferase DOT1 domain
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase
 IPR030445  Histone H3-K79 methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IBA
 biological_processGO:0006281 DNA repair IBA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006342 chromatin silencing IEA
 biological_processGO:0006348 chromatin silencing at telomere IBA
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034729 histone H3-K79 methylation ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0046425 regulation of JAK-STAT cascade ISO
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:2000677 regulation of transcription regulatory region DNA binding ISO
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity ISO
 molecular_functionGO:0031151 histone methyltransferase activity (H3-K79 specific) IEA
 molecular_functionGO:0042054 histone methyltransferase activity ISO


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: B6.B6N-Nlrp3tm1Vmd

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gnetm1.1Masn/Gnetm1.1Masn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Arcn1nur17/Arcn1nur17
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Dot1ltm1Tche/Dot1ltm1.1Tche,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: B6.B6N-Nlrp3tm1Vmd

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arcn1nur17/Arcn1nur17
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6J

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Arcn1nur17/Arcn1nur17
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6J

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: B6.B6N-Nlrp3tm1Vmd

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: B6.B6N-Nlrp3tm1Vmd

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Arcn1nur17/Arcn1nur17
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gnetm1.1Masn/Gnetm1.1Masn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gnetm1.1Masn/Gnetm1.1Masn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: B6.B6N-Nlrp3tm1Vmd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: B6.B6N-Nlrp3tm1Vmd

Allelic Composition: Dot1ltm1Wezh/Dot1ltm1Wezh
Genetic Background: C57BL/6J-Dot1ltm1Wezh

Allelic Composition: Dot1ltm1.1Wezh/Dot1ltm1.1Wezh
Genetic Background: B6(SJL)-Dot1ltm1.1Wezh

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: B6.B6N-Nlrp3tm1Vmd

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dot1ltm1Tche/Dot1ltm1.1Tche,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Dot1ltm1Tche/Dot1ltm1.1Tche,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

 MP:0003155 abnormal telomere length "abnormal length of the terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability; normal length is a few hundred base pairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arcn1nur17/Arcn1nur17
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6J

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Dot1ltm1Tche/Dot1ltm1.1Tche,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Arcn1nur17/Arcn1nur17
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6J

 MP:0003393 decreased cardiac output "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dot1ltm1Tche/Dot1ltm1.1Tche,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: B6.B6N-Nlrp3tm1Vmd

 MP:0003896 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Dot1ltm1Tche/Dot1ltm1.1Tche,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Arcn1nur17/Arcn1nur17
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6J

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Arcn1nur17/Arcn1nur17
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6J

 MP:0004071 prolonged P wave "increase in the length of time of the P wave electrical impulses" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dot1ltm1Tche/Dot1ltm1.1Tche,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: B6.B6N-Nlrp3tm1Vmd

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Robo2tm1Rilm/Robo2tm1Rilm,Olfr160tm4Mom/?,Omptm1(cre)Jae/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S1/Sv

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: B6.B6N-Nlrp3tm1Vmd

 MP:0005460 abnormal leukopoiesis "anomalous process of generating white blood cells (leukocytes) from the pluripotent hematopoietic stem cells of the bone marrow; two significant pathways generate various types of leukocytes: myelopoiesis, in which leukocytes in the blood are derived from myeloid stem cells, and lymphopoiesis, in which leukocytes of the lymphatic system (lymphocytes) are generated from lymphoid stem cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: B6.B6N-Nlrp3tm1Vmd

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Dot1ltm1Tche/Dot1ltm1.1Tche,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arcn1nur17/Arcn1nur17
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6J

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dot1ltm1Tche/Dot1ltm1.1Tche,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: B6.B6N-Nlrp3tm1Vmd

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: B6.B6N-Nlrp3tm1Vmd

 MP:0010392 prolonged QRS complex duration "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dot1ltm1Tche/Dot1ltm1.1Tche,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

 MP:0010506 prolonged RR interval "increase in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dot1ltm1Tche/Dot1ltm1.1Tche,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

 MP:0010519 atrioventricular block "a partial or complete obstruction of the impulse that originates in the atria or sinoatrial node from reaching or transmitting through the atrioventricular node to the ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Dot1ltm1Tche/Dot1ltm1.1Tche,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

 MP:0010559 heart block "a partial or complete obstruction of the propogation of electric impulses through the impulse conduction system of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dot1ltm1Tche/Dot1ltm1.1Tche,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

 MP:0010579 increased heart left ventricle size "greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dot1ltm1Tche/Dot1ltm1.1Tche,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Dot1ltm1Tche/Dot1ltm1.1Tche,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Dnmt1tm1Jrc/Dnmt1tm1Jrc
Genetic Background: involves: 129S1/Sv

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Arcn1nur17/Arcn1nur17
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Dot1ltm1.1Wezh/Dot1ltm1.1Wezh
Genetic Background: B6(SJL)-Dot1ltm1.1Wezh

 MP:0011394 increased fetal cardiomyocyte proliferation "increase in the ability of the differentiating cardiac muscle cell population to undergo expansion by cell division" [MGI:csmith]
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Allelic Composition: Dot1ltm1Tche/Dot1ltm1.1Tche,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Arcn1nur17/Arcn1nur17
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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