ENSG00000105835


Homo sapiens

Features
Gene ID: ENSG00000105835
  
Biological name :NAMPT
  
Synonyms : NAMPT / nicotinamide phosphoribosyltransferase / P43490
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q22.3
Gene start: 106248285
Gene end: 106286326
  
Corresponding Affymetrix probe sets: 1555167_s_at (Human Genome U133 Plus 2.0 Array)   217738_at (Human Genome U133 Plus 2.0 Array)   217739_s_at (Human Genome U133 Plus 2.0 Array)   243296_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000222553
Ensembl peptide - ENSP00000390896
Ensembl peptide - ENSP00000390591
Ensembl peptide - ENSP00000346242
NCBI entrez gene - 10135     See in Manteia.
OMIM - 608764
RefSeq - XM_005250100
RefSeq - NM_005746
RefSeq Peptide - NP_005737
swissprot - A0A024R718
swissprot - C9JF35
swissprot - C9JG65
swissprot - P43490
swissprot - A0A0C4DFS8
Ensembl - ENSG00000105835
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX248331.1ENSDARG00000100321Danio rerio
 CT033790.1ENSDARG00000112678Danio rerio
 namptaENSDARG00000030598Danio rerio
 si:dkey-145c18.2ENSDARG00000076694Danio rerio
 si:dkey-145c18.3ENSDARG00000078738Danio rerio
 NAMPTENSGALG00000008098Gallus gallus
 NamptENSMUSG00000020572Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007229  Nicotinate phosphoribosyltransferase family
 IPR016471  Nicotinamide phosphoribosyl transferase
 IPR036068  Nicotinate phosphoribosyltransferase-like, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0009435 NAD biosynthetic process IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0019363 pyridine nucleotide biosynthetic process IEA
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051770 positive regulation of nitric-oxide synthase biosynthetic process IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0030054 cell junction IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity IEA
 molecular_functionGO:0005125 cytokine activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0047280 nicotinamide phosphoribosyltransferase activity TAS


Pathways (from Reactome)
Pathway description
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Nicotinamide salvaging


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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