ENSMUSG00000020572


Mus musculus

Features
Gene ID: ENSMUSG00000020572
  
Biological name :Nampt
  
Synonyms : Nampt / Nicotinamide phosphoribosyltransferase / Q99KQ4
  
Possible biological names infered from orthology : P43490
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A3
Gene start: 32819545
Gene end: 32853349
  
Corresponding Affymetrix probe sets: 10395259 (MoGene1.0st)   1417190_at (Mouse Genome 430 2.0 Array)   1448607_at (Mouse Genome 430 2.0 Array)   1455320_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152015
Ensembl peptide - ENSMUSP00000020886
NCBI entrez gene - 59027     See in Manteia.
MGI - MGI:1929865
RefSeq - NM_021524
RefSeq Peptide - NP_067499
swissprot - A0A1W2P8A9
swissprot - Q99KQ4
Ensembl - ENSMUSG00000020572
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX248331.1ENSDARG00000100321Danio rerio
 CT033790.1ENSDARG00000112678Danio rerio
 namptaENSDARG00000030598Danio rerio
 si:dkey-145c18.2ENSDARG00000076694Danio rerio
 si:dkey-145c18.3ENSDARG00000078738Danio rerio
 NAMPTENSGALG00000008098Gallus gallus
 NAMPTENSG00000105835Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007229  Nicotinate phosphoribosyltransferase family
 IPR016471  Nicotinamide phosphoribosyl transferase
 IPR036068  Nicotinate phosphoribosyltransferase-like, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0009435 NAD biosynthetic process IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0019363 pyridine nucleotide biosynthetic process IEA
 biological_processGO:0032922 circadian regulation of gene expression IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051770 positive regulation of nitric-oxide synthase biosynthetic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0047280 nicotinamide phosphoribosyltransferase activity IDA


Pathways (from Reactome)
Pathway description
Nicotinamide salvaging


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myo18atm1b(KOMP)Wtsi/Myo18a+
Genetic Background: C57BL/6N-Myo18atm1b(KOMP)Wtsi/Ucd

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Myo18atm1b(KOMP)Wtsi/Myo18a+
Genetic Background: C57BL/6N-Myo18atm1b(KOMP)Wtsi/Ucd

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Myo18atm1b(KOMP)Wtsi/Myo18a+
Genetic Background: C57BL/6N-Myo18atm1b(KOMP)Wtsi/Ucd

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Myo18atm1b(KOMP)Wtsi/Myo18a+
Genetic Background: C57BL/6N-Myo18atm1b(KOMP)Wtsi/Ucd

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Tyrc-11DSD/Tyrc
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Myo18atm1b(KOMP)Wtsi/Myo18a+
Genetic Background: C57BL/6N-Myo18atm1b(KOMP)Wtsi/Ucd

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Myo18atm1b(KOMP)Wtsi/Myo18a+
Genetic Background: C57BL/6N-Myo18atm1b(KOMP)Wtsi/Ucd

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo18atm1b(KOMP)Wtsi/Myo18a+
Genetic Background: C57BL/6N-Myo18atm1b(KOMP)Wtsi/Ucd

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Myo18atm1b(KOMP)Wtsi/Myo18a+
Genetic Background: C57BL/6N-Myo18atm1b(KOMP)Wtsi/Ucd

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Nfe2l2tm1Mym/Nfe2l2tm1Mym,n-TUtca2tm2Mym/n-TUtca2tm2.1Mym,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tyrc-11DSD/Tyrc
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tyrc-11DSD/Tyrc
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tyrc-11DSD/Tyrc
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nfe2l2tm1Mym/Nfe2l2tm1Mym,n-TUtca2tm2Mym/n-TUtca2tm2.1Mym,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfe2l2tm1Mym/Nfe2l2tm1Mym,n-TUtca2tm2Mym/n-TUtca2tm2.1Mym,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Nfe2l2tm1Mym/Nfe2l2tm1Mym,n-TUtca2tm2Mym/n-TUtca2tm2.1Mym,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Nampttm1.1(KOMP)Vlcg/Nampttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nampttm1.1(KOMP)Vlcg/Ucd

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Nampttm1.1(KOMP)Vlcg/Nampttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nampttm1.1(KOMP)Vlcg/Ucd

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Nampttm1.1(KOMP)Vlcg/Nampttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nampttm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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