ENSG00000105854


Homo sapiens

Features
Gene ID: ENSG00000105854
  
Biological name :PON2
  
Synonyms : paraoxonase 2 / PON2 / Q15165
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q21.3
Gene start: 95404863
Gene end: 95435329
  
Corresponding Affymetrix probe sets: 201876_at (Human Genome U133 Plus 2.0 Array)   210830_s_at (Human Genome U133 Plus 2.0 Array)   242700_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000414515
Ensembl peptide - ENSP00000488874
Ensembl peptide - ENSP00000488838
Ensembl peptide - ENSP00000488826
Ensembl peptide - ENSP00000488822
Ensembl peptide - ENSP00000488550
Ensembl peptide - ENSP00000488462
Ensembl peptide - ENSP00000488378
Ensembl peptide - ENSP00000487898
Ensembl peptide - ENSP00000487703
Ensembl peptide - ENSP00000222572
Ensembl peptide - ENSP00000404622
Ensembl peptide - ENSP00000405211
NCBI entrez gene - 5445     See in Manteia.
OMIM - 602447
RefSeq - NM_001018161
RefSeq - XM_017012358
RefSeq - XM_017012357
RefSeq - NM_000305
RefSeq - XM_005250453
RefSeq Peptide - NP_001018171
RefSeq Peptide - NP_000296
swissprot - A0A0J9YYJ1
swissprot - J3QT77
swissprot - Q15165
swissprot - G3XAK4
swissprot - A0A0J9YYG4
swissprot - A0A0J9YYF3
swissprot - A0A0J9YYF0
swissprot - A0A0J9YXU7
swissprot - A0A0J9YXM1
swissprot - A0A0J9YXF2
swissprot - A0A0J9YVW3
Ensembl - ENSG00000105854
  
Related genetic diseases (OMIM): 602447 - {Coronary artery disease, susceptibility to}
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pon1ENSDARG00000032496Danio rerio
 pon2ENSDARG00000016856Danio rerio
 pon3.2ENSDARG00000097789Danio rerio
 pon3.2ENSDARG00000040290Danio rerio
 PON2ENSGALG00000009689Gallus gallus
 Pon2ENSMUSG00000032667Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PON1 / P27169 / paraoxonase 1ENSG0000000542166
PON3 / Q15166 / paraoxonase 3ENSG0000010585265


Protein motifs (from Interpro)
Interpro ID Name
 IPR002640  Arylesterase
 IPR008364  Paraoxonase2
 IPR011042  Six-bladed beta-propeller, TolB-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0009636 response to toxic substance IBA
 biological_processGO:0019372 lipoxygenase pathway TAS
 biological_processGO:0019439 aromatic compound catabolic process IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004064 arylesterase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0102007 acyl-L-homoserine-lactone lactonohydrolase activity TAS


Pathways (from Reactome)
Pathway description
Synthesis of 5-eicosatetraenoic acids


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000217 Xerostomia "Dryness of the mouth due to salivary gland dysfunction." [HPO:curators]
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 HP:0000712 Emotional lability 
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 HP:0000713 Agitation 
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 HP:0000716 Depression "A condition characterized by pervasive dysphoric mood, loss of interests, and inability to experience pleasure." [HPO:curators]
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 HP:0000739 Anxiety 
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 HP:0001257 Spasticity "A motor disorder characterized by a velocity-dependent increase in tonic stretch reflexes with increased muscle tone, exaggerated (hyperexcitable) tendon reflexes." [HPO:curators]
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 HP:0002017 Nausea and vomiting 
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 HP:0002094 Dyspnea 
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 HP:0002180 Neurodegeneration 
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 HP:0002878 Early respiratory failure 
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 HP:0003202 Amyotrophy "The presence of muscular atrophy (which is also known as amyotrophy)." [HPO:curators]
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 HP:0003324 Generalized muscle weakness "Generalized weakness or decreased strength of the muscles." [HPO:curators]
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 HP:0003394 Muscle cramps 
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 HP:0003470 Paralysis "Paralysis of voluntary muscles means loss of contraction due to interruption of one or more motor pathways from the brain to the muscle fibers. Although the word paralysis is often used interchangeably to mean either complete or partial loss of muscle strength, it is preferable to use paralysis or plegia for complete or severe loss of muscle strength, and paresis for partial or slight loss. Motor paralysis results from deficits of the upper motor neurons (corticospinal, corticobulbar, or subcorticospinal). Motor paralysis is often accompanied by an impairment in the facility of movement." [HPO:curators]
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 HP:0005945 Laryngeal obstruction 
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 HP:0007354 Amyotrophic lateral sclerosis 
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 HP:0012378 Fatigue "A subjective feeling of tiredness characterized by a lack of energy and motivation." [HPO:probinson]
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 HP:0012531 Pain "An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage." [ORCID:0000-0001-5208-3432]
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 HP:0030195 Fatigable weakness of swallowing muscles "A type of weakness of the muscles involved in swallowing that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions." [pmid:17986328, UK:rheller]
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 HP:0030196 Fatigable weakness of respiratory muscles "A type of weakness of the muscles involved in breathing (respiration) that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions." [UNCL:mbertoli]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105854 PON2 / Q15165 / paraoxonase 2  / complex






 

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