ENSG00000108771


Homo sapiens

Features
Gene ID: ENSG00000108771
  
Biological name :DHX58
  
Synonyms : DExH-box helicase 58 / DHX58 / Q96C10
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.2
Gene start: 42101404
Gene end: 42112733
  
Corresponding Affymetrix probe sets: 219364_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000404639
Ensembl peptide - ENSP00000467470
Ensembl peptide - ENSP00000466721
Ensembl peptide - ENSP00000416389
Ensembl peptide - ENSP00000251642
NCBI entrez gene - 79132     See in Manteia.
OMIM - 608588
RefSeq - XM_017025060
RefSeq - NM_024119
RefSeq - XM_017025059
RefSeq Peptide - NP_077024
swissprot - K7EPP0
swissprot - C9JG98
swissprot - K7EMZ5
swissprot - Q96C10
swissprot - C9JE76
swissprot - A0A024R1Y5
Ensembl - ENSG00000108771
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dhx58ENSDARG00000089463Danio rerio
 DHX58ENSGALG00000023821Gallus gallus
 Dhx58ENSMUSG00000017830Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IFIH1 / Q9BYX4 / interferon induced with helicase C domain 1ENSG0000011526743
DDX58 / O95786 / DExD/H-box helicase 58ENSG0000010720131
DICER1 / Q9UPY3 / dicer 1, ribonuclease IIIENSG0000010069723
FANCM / Q8IYD8 / Fanconi anemia complementation group MENSG0000018779020


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR006935  Helicase/UvrB, N-terminal
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR021673  RIG-I-like receptor, C-terminal regulatory domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0009615 response to virus ISS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0032480 negative regulation of type I interferon production IDA
 biological_processGO:0032481 positive regulation of type I interferon production ISS
 biological_processGO:0039534 negative regulation of MDA-5 signaling pathway IMP
 biological_processGO:0039536 negative regulation of RIG-I signaling pathway IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045088 regulation of innate immune response IDA
 biological_processGO:0045824 negative regulation of innate immune response IDA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:1900245 positive regulation of MDA-5 signaling pathway ISS
 biological_processGO:1900246 positive regulation of RIG-I signaling pathway ISS
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IDA
 molecular_functionGO:0003727 single-stranded RNA binding IDA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
DDX58/IFIH1-mediated induction of interferon-alpha/beta


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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