ENSG00000110887


Homo sapiens

Features
Gene ID: ENSG00000110887
  
Biological name :DAO
  
Synonyms : D-amino acid oxidase / DAO / P14920
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q24.11
Gene start: 108858932
Gene end: 108901043
  
Corresponding Affymetrix probe sets: 206878_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000449248
Ensembl peptide - ENSP00000446853
Ensembl peptide - ENSP00000449967
Ensembl peptide - ENSP00000447104
Ensembl peptide - ENSP00000448095
Ensembl peptide - ENSP00000228476
NCBI entrez gene - 1610     See in Manteia.
OMIM - 124050
RefSeq - XM_011538005
RefSeq - NM_001917
RefSeq - XM_005268692
RefSeq - XM_011538004
RefSeq Peptide - NP_001908
swissprot - F8W152
swissprot - A0A0B4J257
swissprot - P14920
swissprot - A0A0B4J250
swissprot - A0A024RBI1
swissprot - F8VVT2
swissprot - F8VV35
Ensembl - ENSG00000110887
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dao.1ENSDARG00000035602Danio rerio
 dao.2ENSDARG00000035603Danio rerio
 dao.3ENSDARG00000035601Danio rerio
 DAOENSGALG00000043053Gallus gallus
 DaoENSMUSG00000042096Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DDO / Q99489 / D-aspartate oxidaseENSG0000020379739


Protein motifs (from Interpro)
Interpro ID Name
 IPR006076  FAD dependent oxidoreductase
 IPR006181  D-amino acid oxidase, conserved site
 IPR023209  D-amino-acid oxidase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006562 proline catabolic process IDA
 biological_processGO:0034641 cellular nitrogen compound metabolic process TAS
 biological_processGO:0036088 D-serine catabolic process IDA
 biological_processGO:0042416 dopamine biosynthetic process IDA
 biological_processGO:0046416 D-amino acid metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0055130 D-alanine catabolic process IDA
 biological_processGO:0070178 D-serine metabolic process IDA
 cellular_componentGO:0005741 mitochondrial outer membrane IDA
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005778 peroxisomal membrane IDA
 cellular_componentGO:0005782 peroxisomal matrix TAS
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0003884 D-amino-acid oxidase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046983 protein dimerization activity IDA
 molecular_functionGO:0048037 cofactor binding IDA
 molecular_functionGO:0071949 FAD binding IEA


Pathways (from Reactome)
Pathway description
Glyoxylate metabolism and glycine degradation
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000217 Xerostomia "Dryness of the mouth due to salivary gland dysfunction." [HPO:curators]
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 HP:0000712 Emotional lability 
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 HP:0000713 Agitation 
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 HP:0000716 Depression "A condition characterized by pervasive dysphoric mood, loss of interests, and inability to experience pleasure." [HPO:curators]
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 HP:0000739 Anxiety 
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 HP:0001257 Spasticity "A motor disorder characterized by a velocity-dependent increase in tonic stretch reflexes with increased muscle tone, exaggerated (hyperexcitable) tendon reflexes." [HPO:curators]
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 HP:0002017 Nausea and vomiting 
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 HP:0002094 Dyspnea 
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 HP:0002180 Neurodegeneration 
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 HP:0002878 Early respiratory failure 
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 HP:0003202 Amyotrophy "The presence of muscular atrophy (which is also known as amyotrophy)." [HPO:curators]
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 HP:0003324 Generalized muscle weakness "Generalized weakness or decreased strength of the muscles." [HPO:curators]
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 HP:0003394 Muscle cramps 
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 HP:0003470 Paralysis "Paralysis of voluntary muscles means loss of contraction due to interruption of one or more motor pathways from the brain to the muscle fibers. Although the word paralysis is often used interchangeably to mean either complete or partial loss of muscle strength, it is preferable to use paralysis or plegia for complete or severe loss of muscle strength, and paresis for partial or slight loss. Motor paralysis results from deficits of the upper motor neurons (corticospinal, corticobulbar, or subcorticospinal). Motor paralysis is often accompanied by an impairment in the facility of movement." [HPO:curators]
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 HP:0005945 Laryngeal obstruction 
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 HP:0007354 Amyotrophic lateral sclerosis 
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 HP:0012378 Fatigue "A subjective feeling of tiredness characterized by a lack of energy and motivation." [HPO:probinson]
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 HP:0012531 Pain "An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage." [ORCID:0000-0001-5208-3432]
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 HP:0030195 Fatigable weakness of swallowing muscles "A type of weakness of the muscles involved in swallowing that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions." [pmid:17986328, UK:rheller]
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 HP:0030196 Fatigable weakness of respiratory muscles "A type of weakness of the muscles involved in breathing (respiration) that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions." [UNCL:mbertoli]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110887 DAO / P14920 / D-amino acid oxidase  / complex






 

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