ENSG00000112115


Homo sapiens

Features
Gene ID: ENSG00000112115
  
Biological name :IL17A
  
Synonyms : IL17A / interleukin 17A / Q16552
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p12.2
Gene start: 52186387
Gene end: 52190638
  
Corresponding Affymetrix probe sets: 208402_at (Human Genome U133 Plus 2.0 Array)   216876_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000344192
NCBI entrez gene - 3605     See in Manteia.
OMIM - 603149
RefSeq - NM_002190
RefSeq Peptide - NP_002181
swissprot - Q16552
Ensembl - ENSG00000112115
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il17a/f1ENSDARG00000043933Danio rerio
 il17a/f3ENSDARG00000041976Danio rerio
 ENSGALG00000016677Gallus gallus
 IL17AENSGALG00000016678Gallus gallus
 Il17aENSMUSG00000025929Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IL17F / Q96PD4 / interleukin 17FENSG0000011211643


Protein motifs (from Interpro)
Interpro ID Name
 IPR010345  Interleukin-17 family
 IPR020440  Interleukin-17, chordata
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0008219 cell death TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0032747 positive regulation of interleukin-23 production IDA
 biological_processGO:0045672 positive regulation of osteoclast differentiation IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050832 defense response to fungus IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0072537 fibroblast activation IDA
 biological_processGO:0097400 interleukin-17-mediated signaling pathway TAS
 biological_processGO:1900017 positive regulation of cytokine production involved in inflammatory response IEA
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 molecular_functionGO:0005125 cytokine activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-17 signaling
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000177663 IL17RA / Q96F46 / interleukin 17 receptor A  / complex
 ENSG00000112116 IL17F / Q96PD4 / interleukin 17F  / complex
 ENSG00000163702 IL17RC / Q8NAC3 / interleukin 17 receptor C  / complex
 ENSG00000112115 IL17A / Q16552 / interleukin 17A  / complex






 

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