ENSG00000112293


Homo sapiens

Features
Gene ID: ENSG00000112293
  
Biological name :GPLD1
  
Synonyms : glycosylphosphatidylinositol specific phospholipase D1 / GPLD1 / P80108
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p22.3
Gene start: 24424565
Gene end: 24495205
  
Corresponding Affymetrix probe sets: 206264_at (Human Genome U133 Plus 2.0 Array)   206265_s_at (Human Genome U133 Plus 2.0 Array)   206266_at (Human Genome U133 Plus 2.0 Array)   215554_at (Human Genome U133 Plus 2.0 Array)   217405_x_at (Human Genome U133 Plus 2.0 Array)   238752_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000230036
NCBI entrez gene - 2822     See in Manteia.
OMIM - 602515
RefSeq - XM_017010754
RefSeq - NM_001503
RefSeq - XM_011514509
RefSeq - XM_017010753
RefSeq Peptide - NP_001494
swissprot - P80108
Ensembl - ENSG00000112293
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000040330Gallus gallus
 ENSGALG00000029836Gallus gallus
 Gpld1ENSMUSG00000021340Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001028  Glycoprotein phospholipase D
 IPR013517  FG-GAP repeat
 IPR013519  Integrin alpha beta-propellor
 IPR029002  Phospholipase C/D


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification ISS
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis IMP
 biological_processGO:0002062 chondrocyte differentiation ISS
 biological_processGO:0002430 complement receptor mediated signaling pathway IDA
 biological_processGO:0006501 C-terminal protein lipidation TAS
 biological_processGO:0006507 GPI anchor release IMP
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0008286 insulin receptor signaling pathway IDA
 biological_processGO:0009749 response to glucose IDA
 biological_processGO:0010595 positive regulation of endothelial cell migration IMP
 biological_processGO:0010694 positive regulation of alkaline phosphatase activity ISS
 biological_processGO:0010867 positive regulation of triglyceride biosynthetic process ISS
 biological_processGO:0010897 negative regulation of triglyceride catabolic process ISS
 biological_processGO:0010907 positive regulation of glucose metabolic process ISS
 biological_processGO:0010983 positive regulation of high-density lipoprotein particle clearance ISS
 biological_processGO:0032869 cellular response to insulin stimulus IDA
 biological_processGO:0035690 cellular response to drug IDA
 biological_processGO:0035701 hematopoietic stem cell migration TAS
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus ISS
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0045919 positive regulation of cytolysis IDA
 biological_processGO:0046470 phosphatidylcholine metabolic process TAS
 biological_processGO:0051044 positive regulation of membrane protein ectodomain proteolysis IDA
 biological_processGO:0051047 positive regulation of secretion ISS
 biological_processGO:0070633 transepithelial transport ISS
 biological_processGO:0071277 cellular response to calcium ion IDA
 biological_processGO:0071397 cellular response to cholesterol IMP
 biological_processGO:0071401 cellular response to triglyceride IMP
 biological_processGO:0071467 cellular response to pH IDA
 biological_processGO:0097241 hematopoietic stem cell migration to bone marrow TAS
 biological_processGO:1900076 regulation of cellular response to insulin stimulus IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005765 lysosomal membrane HDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004621 glycosylphosphatidylinositol phospholipase D activity TAS
 molecular_functionGO:0004630 phospholipase D activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017080 sodium channel regulator activity ISS


Pathways (from Reactome)
Pathway description
Post-translational modification: synthesis of GPI-anchored proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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