ENSMUSG00000021340


Mus musculus

Features
Gene ID: ENSMUSG00000021340
  
Biological name :Gpld1
  
Synonyms : glycosylphosphatidylinositol specific phospholipase D1 / Gpld1
  
Possible biological names infered from orthology : P80108
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A3.1
Gene start: 24943152
Gene end: 24992501
  
Corresponding Affymetrix probe sets: 10404218 (MoGene1.0st)   1418050_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021773
NCBI entrez gene - 14756     See in Manteia.
MGI - MGI:106604
RefSeq - XM_017315392
RefSeq - NM_008156
RefSeq - XM_017315390
RefSeq - XM_017315391
RefSeq - XM_011244282
RefSeq Peptide - NP_032182
swissprot - Q8VCU2
Ensembl - ENSMUSG00000021340
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000040330Gallus gallus
 ENSGALG00000029836Gallus gallus
 GPLD1ENSG00000112293Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001028  Glycoprotein phospholipase D
 IPR013517  FG-GAP repeat
 IPR013519  Integrin alpha beta-propellor
 IPR029002  Phospholipase C/D


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis IEA
 biological_processGO:0002430 complement receptor mediated signaling pathway IEA
 biological_processGO:0006507 GPI anchor release IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045919 positive regulation of cytolysis IEA
 biological_processGO:0051044 positive regulation of membrane protein ectodomain proteolysis IEA
 biological_processGO:0071277 cellular response to calcium ion IEA
 biological_processGO:0071397 cellular response to cholesterol IEA
 biological_processGO:0071401 cellular response to triglyceride IEA
 biological_processGO:0071467 cellular response to pH IEA
 biological_processGO:1900076 regulation of cellular response to insulin stimulus IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004621 glycosylphosphatidylinositol phospholipase D activity IEA
 molecular_functionGO:0004630 phospholipase D activity IEA


Pathways (from Reactome)
Pathway description
Post-translational modification: synthesis of GPI-anchored proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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