ENSG00000113389


Homo sapiens

Features
Gene ID: ENSG00000113389
  
Biological name :NPR3
  
Synonyms : natriuretic peptide receptor 3 / NPR3 / P17342
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: p13.3
Gene start: 32689070
Gene end: 32791724
  
Corresponding Affymetrix probe sets: 219054_at (Human Genome U133 Plus 2.0 Array)   219789_at (Human Genome U133 Plus 2.0 Array)   219790_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000398028
Ensembl peptide - ENSP00000388408
Ensembl peptide - ENSP00000423730
Ensembl peptide - ENSP00000425325
Ensembl peptide - ENSP00000265074
Ensembl peptide - ENSP00000318340
NCBI entrez gene - 4883     See in Manteia.
OMIM - 108962
RefSeq - XM_017009492
RefSeq - NM_000908
RefSeq - NM_001204375
RefSeq - NM_001204376
RefSeq - XM_005248309
RefSeq - XM_011514047
RefSeq - XM_011514048
RefSeq - XM_011514049
RefSeq - XM_011514050
RefSeq Peptide - NP_000899
RefSeq Peptide - NP_001191304
RefSeq Peptide - NP_001191305
swissprot - Q60I31
swissprot - D6RDL8
swissprot - C9JK69
swissprot - H0Y9B9
swissprot - P17342
Ensembl - ENSG00000113389
  
Related genetic diseases (OMIM): 108962 - ?Hypertension, salt-resistant
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 npr3ENSDARG00000035253Danio rerio
 NPR3ENSGALG00000017405Gallus gallus
 Npr3ENSMUSG00000022206Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001170  Adenylyl cyclase class-4/guanylyl cyclase
 IPR001828  Receptor, ligand binding region
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development ISS
 biological_processGO:0002158 osteoclast proliferation ISS
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007194 negative regulation of adenylate cyclase activity IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008217 regulation of blood pressure ISS
 biological_processGO:0030157 pancreatic juice secretion IEA
 biological_processGO:0033688 regulation of osteoblast proliferation ISS
 biological_processGO:0035810 positive regulation of urine volume ISS
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity ISS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005887 integral component of plasma membrane IC
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008528 G-protein coupled peptide receptor activity ISS
 molecular_functionGO:0016941 natriuretic peptide receptor activity IDA
 molecular_functionGO:0017046 peptide hormone binding ISS
 molecular_functionGO:0031404 chloride ion binding IDA
 molecular_functionGO:0042277 peptide binding IPI
 molecular_functionGO:0042562 hormone binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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