ENSMUSG00000022206


Mus musculus

Features
Gene ID: ENSMUSG00000022206
  
Biological name :Npr3
  
Synonyms : natriuretic peptide receptor 3 / Npr3 / P70180
  
Possible biological names infered from orthology : P17342
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: A1
Gene start: 11839896
Gene end: 11907287
  
Corresponding Affymetrix probe sets: 10427796 (MoGene1.0st)   1435184_at (Mouse Genome 430 2.0 Array)   1448024_at (Mouse Genome 430 2.0 Array)   1450286_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000066737
Ensembl peptide - ENSMUSP00000153895
Ensembl peptide - ENSMUSP00000154180
NCBI entrez gene - 18162     See in Manteia.
MGI - MGI:97373
RefSeq - XM_017316493
RefSeq - NM_001039181
RefSeq - NM_001286395
RefSeq - NM_008728
RefSeq - XM_006520028
RefSeq - XM_006520030
RefSeq - XM_006520031
RefSeq Peptide - NP_001034270
RefSeq Peptide - NP_001273324
RefSeq Peptide - NP_032754
swissprot - Q7TMG7
swissprot - P70180
Ensembl - ENSMUSG00000022206
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 npr3ENSDARG00000035253Danio rerio
 NPR3ENSGALG00000017405Gallus gallus
 NPR3ENSG00000113389Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001170  Adenylyl cyclase class-4/guanylyl cyclase
 IPR001828  Receptor, ligand binding region
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IDA
 biological_processGO:0002158 osteoclast proliferation IMP
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007194 negative regulation of adenylate cyclase activity IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0030157 pancreatic juice secretion IEA
 biological_processGO:0033688 regulation of osteoblast proliferation IMP
 biological_processGO:0035810 positive regulation of urine volume IMP
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0008528 G-protein coupled peptide receptor activity IEA
 molecular_functionGO:0016941 natriuretic peptide receptor activity IEA
 molecular_functionGO:0017046 peptide hormone binding IEA
 molecular_functionGO:0031404 chloride ion binding IEA
 molecular_functionGO:0042277 peptide binding IEA
 molecular_functionGO:0042562 hormone binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000003 abnormal adipose tissue morphology "structural anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Arpc3Tn(sb-lacZ,GFP)T5.117Jtak/Arpc3tm1Jtak
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Npr3lgj-2J/Npr3lgj-2J
Genetic Background: DBA/2J

 MP:0000010 abnormal abdominal fat pads "malformed or aberrant size of the encapsulated adipose tissue in the abdomen" [J:65146]
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Allelic Composition: Arpc3Tn(sb-lacZ,GFP)T5.117Jtak/Arpc3tm1Jtak
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Npr3lgj-2J/Npr3lgj-2J
Genetic Background: DBA/2J

Allelic Composition: Npr3stri/Npr3stri
Genetic Background: involves: 129/Sv * FVB/N

 MP:0000013 abnormal fat distribution "alterations in the normal placement and amount of body fat" [J:57315]
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Allelic Composition: Arpc3Tn(sb-lacZ,GFP)T5.117Jtak/Arpc3tm1Jtak
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Npr3lgj-2J/Npr3lgj-2J
Genetic Background: DBA/2J

Allelic Composition: Npr3stri/Npr3stri
Genetic Background: involves: 129/Sv * FVB/N

 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Npr3lgj/Npr3lgj
Genetic Background: BALB/cJ

Allelic Composition: Npr3lgj-2J/Npr3lgj-2J
Genetic Background: DBA/2J

Allelic Composition: Npr3stri/Npr3stri
Genetic Background: involves: 129/Sv * FVB/N

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Npr3lgj-2J/Npr3lgj-2J
Genetic Background: DBA/2J

Allelic Composition: Npr3stri/Npr3stri
Genetic Background: involves: 129/Sv * FVB/N

Allelic Composition: Npr3lgj-3J/Npr3lgj-3J
Genetic Background: C57BL/6J-Npr3lgj-3J/GrsrJ

Allelic Composition: Npr3m1Btlr/Npr3m1Btlr
Genetic Background: C57BL/6J-Npr3m1Btlr

Allelic Composition: Npr3lgj-4J/Npr3lgj-4J
Genetic Background: NOD/ShiLtJ

Allelic Composition: Npr3skm1/Npr3skm1
Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * DBA/2J

 MP:0000440 domed skull 
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000554 abnormal carpal bone morphology "malformation of the nine nodular bones of the joint between the forelimb bones and the front paws consisting of the scapholunar, triangular, greater multiangular, lesser multiangular, capitate, hamate, centrale and the sesamoids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Npr3stri/Npr3stri
Genetic Background: involves: 129/Sv * FVB/N

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Npr3lgj/Npr3lgj
Genetic Background: BALB/cJ

Allelic Composition: Npr3lgj-2J/Npr3lgj-2J
Genetic Background: DBA/2J

Allelic Composition: Npr3lgj-3J/Npr3lgj-3J
Genetic Background: C57BL/6J-Npr3lgj-3J/GrsrJ

Allelic Composition: Npr3lgj-4J/Npr3lgj-4J
Genetic Background: NOD/ShiLtJ

Allelic Composition: Npr3skm1/Npr3skm1
Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * DBA/2J

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Npr3m1Btlr/Npr3m1Btlr
Genetic Background: C57BL/6J-Npr3m1Btlr

Allelic Composition: Npr3lgj-4J/Npr3lgj-4J
Genetic Background: NOD/ShiLtJ

Allelic Composition: Npr3skm1/Npr3skm1
Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * DBA/2J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001596 hypotension "sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Npr3tm1Unc/Npr3+
Genetic Background: involves: 129 * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Npr3lgj-2J/Npr3lgj-2J
Genetic Background: DBA/2J

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ndntm1.1Mus/Ndn+
Genetic Background: B6.129S2-Ndntm1.1Mus

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Npr3lgj/Npr3lgj
Genetic Background: BALB/cJ

Allelic Composition: Npr3lgj-2J/Npr3lgj-2J
Genetic Background: DBA/2J

Allelic Composition: Npr3stri/Npr3stri
Genetic Background: involves: 129/Sv * FVB/N

Allelic Composition: Npr3lgj-3J/Npr3lgj-3J
Genetic Background: C57BL/6J-Npr3lgj-3J/GrsrJ

Allelic Composition: Npr3skm1/Npr3skm1
Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * DBA/2J

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Arpc3Tn(sb-lacZ,GFP)T5.117Jtak/Arpc3tm1Jtak
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Npr3lgj-2J/Npr3lgj-2J
Genetic Background: DBA/2J

Allelic Composition: Npr3stri/Npr3stri
Genetic Background: involves: 129/Sv * FVB/N

Allelic Composition: Npr3lgj-3J/Npr3lgj-3J
Genetic Background: C57BL/6J-Npr3lgj-3J/GrsrJ

 MP:0002115 abnormal skeleton extremities morphology "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Npr3stri/Npr3stri
Genetic Background: involves: 129/Sv * FVB/N

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Npr3tm1Unc/Npr3+
Genetic Background: involves: 129 * C57BL/6

 MP:0002758 long tail "increased length of tail relative to average of a given strain" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Npr3m1Btlr/Npr3m1Btlr
Genetic Background: C57BL/6J-Npr3m1Btlr

 MP:0002759 abnormal caudal vertebrae morphology "malformed bony segments of the tail, usually 27-30 present" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]
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Allelic Composition: Npr3lgj/Npr3lgj
Genetic Background: BALB/cJ

Allelic Composition: Npr3lgj-2J/Npr3lgj-2J
Genetic Background: DBA/2J

Allelic Composition: Npr3stri/Npr3stri
Genetic Background: involves: 129/Sv * FVB/N

Allelic Composition: Npr3lgj-4J/Npr3lgj-4J
Genetic Background: NOD/ShiLtJ

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Npr3tm1Unc/Npr3+
Genetic Background: involves: 129 * C57BL/6

 MP:0002998 abnormal bone remodeling "aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003050 abnormal sacral vertebrae morphology "malformation of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Npr3lgj/Npr3lgj
Genetic Background: BALB/cJ

Allelic Composition: Npr3lgj-2J/Npr3lgj-2J
Genetic Background: DBA/2J

Allelic Composition: Npr3stri/Npr3stri
Genetic Background: involves: 129/Sv * FVB/N

 MP:0003073 abnormal metacarpal bone morphology "anomaly in the five bones of the forepaws that articulate proximally with the carpal bones and distally with the phlanges" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Npr3stri/Npr3stri
Genetic Background: involves: 129/Sv * FVB/N

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Npr3tm1Unc/Npr3+
Genetic Background: involves: 129 * C57BL/6

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
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Allelic Composition: Npr3stri/Npr3stri
Genetic Background: involves: 129/Sv * FVB/N

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004619 caudal vertebral fusion "the union of one or more caudal vertebrae into a single structure in species where this does not normally occur" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npr3skm1/Npr3skm1
Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * DBA/2J

 MP:0004624 abnormal thoracic cage "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npr3lgj/Npr3lgj
Genetic Background: BALB/cJ

Allelic Composition: Npr3lgj-2J/Npr3lgj-2J
Genetic Background: DBA/2J

 MP:0004641 elongated metatarsal bones "increased length of the five bones of the hindpaws/feet that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004651 increased thoracic vertebrae number "increased number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Npr3stri/Npr3stri
Genetic Background: involves: 129/Sv * FVB/N

 MP:0004685 intervertebral calcification "process in which the cartilaginous and gelatinous structure found between vertebrae becomes hardened due to deposits of calcium salts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npr3stri/Npr3stri
Genetic Background: involves: 129/Sv * FVB/N

 MP:0004695 increased length of long bones "greater end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Npr3lgj-4J/Npr3lgj-4J
Genetic Background: NOD/ShiLtJ

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npr3lgj-3J/Npr3lgj-3J
Genetic Background: C57BL/6J-Npr3lgj-3J/GrsrJ

 MP:0004705 elongated vertebral body "increased length of the main cylindrical portion of the vertebra ventral to the vertebral canal" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005225 abnormal vertebrae development "anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Npr3stri/Npr3stri
Genetic Background: involves: 129/Sv * FVB/N

 MP:0005229 abnormal intervertebral disk development "anomalous fromation of the cartilagenous and gelatinous structure found between vertebrae" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Npr3stri/Npr3stri
Genetic Background: involves: 129/Sv * FVB/N

 MP:0005306 abnormal phalanx morphology "aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Npr3stri/Npr3stri
Genetic Background: involves: 129/Sv * FVB/N

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Npr3tm1Unc/Npr3+
Genetic Background: involves: 129 * C57BL/6

 MP:0006253 clinodactyly "abnormal lateral curvature of one or more digits towards or away from each other" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:98519]
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Allelic Composition: Npr3lgj-3J/Npr3lgj-3J
Genetic Background: C57BL/6J-Npr3lgj-3J/GrsrJ

 MP:0006296 arachnodactyly "the digits are abnormally long and slender" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Npr3lgj/Npr3lgj
Genetic Background: BALB/cJ

Allelic Composition: Npr3lgj-2J/Npr3lgj-2J
Genetic Background: DBA/2J

Allelic Composition: Npr3lgj-4J/Npr3lgj-4J
Genetic Background: NOD/ShiLtJ

Allelic Composition: Npr3skm1/Npr3skm1
Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * DBA/2J

 MP:0006320 abnormal interscapular fat pad "any structural anomaly of the encapsulated adipose tissue located between the scapulae" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,X/Yaa
Genetic Background: BXSB.129S2(B6)-Cd8atm1Mak/4Dcr

 MP:0006392 abnormal nucleus pulposus morphology "any anomaly in the structure or formation of the jelly-like substance in the middle of the spinal disc which is a remnant of the notochord" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Npr3stri/Npr3stri
Genetic Background: involves: 129/Sv * FVB/N

 MP:0006393 absent nucleus pulposus "missing the notochord remnant normally found in the center of the intervetebral disc" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Npr3stri/Npr3stri
Genetic Background: involves: 129/Sv * FVB/N

 MP:0006394 abnormal vertebral epiphyseal plate morphology "any structural anomaly in the lateral cartilaginous centers of ossification; may be found on the lateral, upper, and/or lower surfaces of the vertebrae at different times during development" [ISBN:0-914294-08-3 "Gray s Anatomy", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Npr3stri/Npr3stri
Genetic Background: involves: 129/Sv * FVB/N

 MP:0008771 elongated vertebral column "increased rostral-caudal length of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npr3m1Btlr/Npr3m1Btlr
Genetic Background: C57BL/6J-Npr3m1Btlr

 MP:0008833 caudal hemivertebra "a congenital malformation of the caudal vertebrae in which only half of the vertebral body develops" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Npr3skm1/Npr3skm1
Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * DBA/2J

 MP:0009125 decreased brown fat cell lipid droplet size "reduction in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,X/Yaa
Genetic Background: BXSB.129S2(B6)-Cd8atm1Mak/4Dcr

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,X/Yaa
Genetic Background: BXSB.129S2(B6)-Cd8atm1Mak/4Dcr

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,X/Yaa
Genetic Background: BXSB.129S2(B6)-Cd8atm1Mak/4Dcr

 MP:0009293 decreased inguinal fat pad weight 
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,X/Yaa
Genetic Background: BXSB.129S2(B6)-Cd8atm1Mak/4Dcr

 MP:0009295 decreased interscapular fat pad weight 
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,X/Yaa
Genetic Background: BXSB.129S2(B6)-Cd8atm1Mak/4Dcr

 MP:0009305 decreased retroperitoneal fat pad weight 
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,X/Yaa
Genetic Background: BXSB.129S2(B6)-Cd8atm1Mak/4Dcr

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0010103 small thoracic cage "reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0010128 hypovolemia "an abnormally decreased amount of space occupied by blood in the vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Npr3tm1Unc/Npr3+
Genetic Background: involves: 129 * C57BL/6

 MP:0010867 abnormal bone trabecula morphology "any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011476 abnormal urine nucleotide level "any change in the urinary level of glycosamines consisting of a nucleobase, a five-carbon sugar moiety (ribose or deoxyribose), and may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)" [MGI:csmith]
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Allelic Composition: Hellstm1Rarc/Hellstm1Rarc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Npr3tm1Unc/Npr3+
Genetic Background: involves: 129 * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Npr3lgj-3J/Npr3lgj-3J
Genetic Background: C57BL/6J-Npr3lgj-3J/GrsrJ

 MP:0013138 thin body "lean or slender in form" [MGI:Ahmad_Retha]
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Allelic Composition: Npr3skm1/Npr3skm1
Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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