ENSG00000113407


Homo sapiens

Features
Gene ID: ENSG00000113407
  
Biological name :TARS
  
Synonyms : P26639 / TARS / threonyl-tRNA synthetase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: p13.3
Gene start: 33440696
Gene end: 33469539
  
Corresponding Affymetrix probe sets: 201263_at (Human Genome U133 Plus 2.0 Array)   240206_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000422130
Ensembl peptide - ENSP00000422291
Ensembl peptide - ENSP00000486893
Ensembl peptide - ENSP00000486068
Ensembl peptide - ENSP00000427627
Ensembl peptide - ENSP00000427304
Ensembl peptide - ENSP00000425524
Ensembl peptide - ENSP00000424387
Ensembl peptide - ENSP00000422598
Ensembl peptide - ENSP00000265112
Ensembl peptide - ENSP00000387710
Ensembl peptide - ENSP00000420893
NCBI entrez gene - 6897     See in Manteia.
OMIM - 187790
RefSeq - NM_001258438
RefSeq - NM_152295
RefSeq - NM_001258437
RefSeq Peptide - NP_001245366
RefSeq Peptide - NP_001245367
RefSeq Peptide - NP_689508
swissprot - D6R9F8
swissprot - D6RJ97
swissprot - P26639
swissprot - D6RHV7
swissprot - D6RDJ6
swissprot - D6RCS6
swissprot - D6RCA5
swissprot - D6RBR8
Ensembl - ENSG00000113407
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tarsENSDARG00000013250Danio rerio
 TARSENSGALG00000003288Gallus gallus
 TarsENSMUSG00000022241Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A2RTX5 / TARSL2 / threonyl-tRNA synthetase like 2ENSG0000018541868
TARS2 / Q9BW92 / threonyl-tRNA synthetase 2, mitochondrialENSG0000014337449
MRPL39 / Q9NYK5 / mitochondrial ribosomal protein L39ENSG0000015471911


Protein motifs (from Interpro)
Interpro ID Name
 IPR002314  Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
 IPR002320  Threonine-tRNA ligase, class IIa
 IPR004095  TGS
 IPR004154  Anticodon-binding
 IPR006195  Aminoacyl-tRNA synthetase, class II
 IPR012675  Beta-grasp domain superfamily
 IPR012676  TGS-like
 IPR012947  Threonyl/alanyl tRNA synthetase, SAD
 IPR018163  Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily
 IPR033728  Threonine-tRNA ligase catalytic core domain
 IPR036621  Anticodon-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation NAS
 biological_processGO:0006418 tRNA aminoacylation for protein translation TAS
 biological_processGO:0006435 threonyl-tRNA aminoacylation IEA
 biological_processGO:0043039 tRNA aminoacylation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000049 tRNA binding IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004812 aminoacyl-tRNA ligase activity IEA
 molecular_functionGO:0004829 threonine-tRNA ligase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity NAS


Pathways (from Reactome)
Pathway description
Cytosolic tRNA aminoacylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000113407 TARS / P26639 / threonyl-tRNA synthetase  / complex






 

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