ENSG00000115977


Homo sapiens

Features
Gene ID: ENSG00000115977
  
Biological name :AAK1
  
Synonyms : AAK1 / AP2 associated kinase 1 / Q2M2I8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p13.3
Gene start: 69457997
Gene end: 69674349
  
Corresponding Affymetrix probe sets: 205434_s_at (Human Genome U133 Plus 2.0 Array)   205435_s_at (Human Genome U133 Plus 2.0 Array)   211186_s_at (Human Genome U133 Plus 2.0 Array)   214956_at (Human Genome U133 Plus 2.0 Array)   214998_at (Human Genome U133 Plus 2.0 Array)   225522_at (Human Genome U133 Plus 2.0 Array)   238100_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000385181
Ensembl peptide - ENSP00000485409
Ensembl peptide - ENSP00000485350
Ensembl peptide - ENSP00000485296
Ensembl peptide - ENSP00000386456
Ensembl peptide - ENSP00000386342
NCBI entrez gene - 22848     See in Manteia.
OMIM - 616405
RefSeq - NM_014911
RefSeq Peptide - NP_055726
swissprot - A0A096LNZ0
swissprot - E9PG46
swissprot - Q2M2I8
swissprot - A0A096LP60
swissprot - A0A096LP25
Ensembl - ENSG00000115977
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aak1aENSDARG00000011855Danio rerio
 aak1bENSDARG00000077686Danio rerio
 AAK1ENSGALG00000041911Gallus gallus
 Aak1ENSMUSG00000057230Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BMP2K / Q9NSY1 / BMP2 inducible kinaseENSG0000013875640


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011989  Armadillo-like helical
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR028182  BMP-2-inducible protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032880 regulation of protein localization IDA
 biological_processGO:0045747 positive regulation of Notch signaling pathway IDA
 biological_processGO:0046777 protein autophosphorylation ISS
 biological_processGO:0050821 protein stabilization IDA
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:2000369 regulation of clathrin-dependent endocytosis IMP
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019897 extrinsic component of plasma membrane ISS
 cellular_componentGO:0030136 clathrin-coated vesicle ISS
 cellular_componentGO:0031252 cell leading edge ISS
 cellular_componentGO:0043195 terminal bouton ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0005112 Notch binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035612 AP-2 adaptor complex binding IDA


Pathways (from Reactome)
Pathway description
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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