ENSMUSG00000057230


Mus musculus

Features
Gene ID: ENSMUSG00000057230
  
Biological name :Aak1
  
Synonyms : Aak1 / AP2 associated kinase 1 / Q3UHJ0
  
Possible biological names infered from orthology : Q2M2I8
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: D1
Gene start: 86849517
Gene end: 87003223
  
Corresponding Affymetrix probe sets: 10539741 (MoGene1.0st)   10539766 (MoGene1.0st)   1420025_s_at (Mouse Genome 430 2.0 Array)   1420026_at (Mouse Genome 430 2.0 Array)   1434935_at (Mouse Genome 430 2.0 Array)   1435038_s_at (Mouse Genome 430 2.0 Array)   1441782_at (Mouse Genome 430 2.0 Array)   1452632_at (Mouse Genome 430 2.0 Array)   1452633_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003710
Ensembl peptide - ENSMUSP00000086948
Ensembl peptide - ENSMUSP00000145013
NCBI entrez gene - 269774     See in Manteia.
MGI - MGI:1098687
RefSeq - XM_017321597
RefSeq - NM_001040106
RefSeq - NM_177762
RefSeq - XM_006506191
RefSeq - XM_006506192
RefSeq Peptide - NP_001035195
RefSeq Peptide - NP_808430
swissprot - Q3UHJ0
swissprot - A0A0N4SVA1
Ensembl - ENSMUSG00000057230
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aak1aENSDARG00000011855Danio rerio
 aak1bENSDARG00000077686Danio rerio
 AAK1ENSGALG00000041911Gallus gallus
 AAK1ENSG00000115977Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bmp2k / Q91Z96 / BMP-2-inducible protein kinase / Q9NSY1* / BMP2 inducible kinase*ENSMUSG0000003466339


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011989  Armadillo-like helical
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032880 regulation of protein localization ISS
 biological_processGO:0045747 positive regulation of Notch signaling pathway IBA
 biological_processGO:0046777 protein autophosphorylation ISS
 biological_processGO:0050821 protein stabilization ISS
 biological_processGO:2000369 regulation of clathrin-dependent endocytosis ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019897 extrinsic component of plasma membrane ISS
 cellular_componentGO:0030136 clathrin-coated vesicle ISS
 cellular_componentGO:0031252 cell leading edge ISS
 cellular_componentGO:0043195 terminal bouton ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005112 Notch binding ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035612 AP-2 adaptor complex binding ISO


Pathways (from Reactome)
Pathway description
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: A830005F24Riktm1.1(KOMP)Mbp/A830005F24Rik+
Genetic Background: C57BL/6N-A830005F24Riktm1.1(KOMP)Mbp/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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