ENSG00000116237


Homo sapiens

Features
Gene ID: ENSG00000116237
  
Biological name :ICMT
  
Synonyms : ICMT / isoprenylcysteine carboxyl methyltransferase / O60725
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p36.31
Gene start: 6221193
Gene end: 6235972
  
Corresponding Affymetrix probe sets: 201609_x_at (Human Genome U133 Plus 2.0 Array)   201610_at (Human Genome U133 Plus 2.0 Array)   201611_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000467999
Ensembl peptide - ENSP00000343552
Ensembl peptide - ENSP00000466222
NCBI entrez gene - 23463     See in Manteia.
OMIM - 605851
RefSeq - XM_011541140
RefSeq - NM_012405
RefSeq Peptide - NP_036537
swissprot - A0A024R4F6
swissprot - O60725
swissprot - Q7Z750
swissprot - K7EQW0
Ensembl - ENSG00000116237
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 icmtENSDARG00000020241Danio rerio
 ICMTENSGALG00000024053Gallus gallus
 IcmtENSMUSG00000039662Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007269  Isoprenylcysteine carboxyl methyltransferase
 IPR025770  Protein-S-isoprenylcysteine O-methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006464 cellular protein modification process TAS
 biological_processGO:0006481 C-terminal protein methylation TAS
 biological_processGO:0006612 protein targeting to membrane TAS
 biological_processGO:0032259 methylation IEA
 biological_processGO:0043687 post-translational protein modification TAS
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003880 protein C-terminal carboxyl O-methyltransferase activity TAS
 molecular_functionGO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity TAS
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Gamma carboxylation, hypusine formation and arylsulfatase activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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