ENSMUSG00000039662


Mus musculus

Features
Gene ID: ENSMUSG00000039662
  
Biological name :Icmt
  
Synonyms : Icmt / isoprenylcysteine carboxyl methyltransferase
  
Possible biological names infered from orthology : O60725
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: E2
Gene start: 152297227
Gene end: 152307121
  
Corresponding Affymetrix probe sets: 10510708 (MoGene1.0st)   1426500_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043390
Ensembl peptide - ENSMUSP00000133950
NCBI entrez gene - 57295     See in Manteia.
MGI - MGI:1888594
RefSeq - NM_133788
RefSeq Peptide - NP_598549
swissprot - Q3U4N2
swissprot - Q6PGA6
Ensembl - ENSMUSG00000039662
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 icmtENSDARG00000020241Danio rerio
 ICMTENSGALG00000024053Gallus gallus
 ICMTENSG00000116237Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007269  Isoprenylcysteine carboxyl methyltransferase
 IPR025770  Protein-S-isoprenylcysteine O-methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006481 C-terminal protein methylation IEA
 biological_processGO:0032259 methylation IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Gamma carboxylation, hypusine formation and arylsulfatase activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0000596 abnormal liver development "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0000597 delayed hepatic development "late onset of the induction and/or differentiation of the liver" [J:18048]
Show

Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

Allelic Composition: Icmttm1Sgy/Icmttm1Sgy
Genetic Background: Not Specified

 MP:0011877 absent liver "absence of the bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage" [MGI:Colin_McKerlie]
Show

Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0012235 abnormal liver bud morphology "any structural anomaly of the liver primordium formed as hepatoblasts delaminate from the anterior portion of the hepatic diverticulum and invade the adjacent septum transversum mesenchyme" [MGI:anna]
Show

Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0012504 increased forebrain apoptosis "increase in the number of cells of the forebrain undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0012505 increased neural tube apoptosis "increase in the number of cells of the neural tube undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr