ENSG00000116824


Homo sapiens

Features
Gene ID: ENSG00000116824
  
Biological name :CD2
  
Synonyms : CD2 / CD2 molecule / P06729
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p13.1
Gene start: 116754385
Gene end: 116769228
  
Corresponding Affymetrix probe sets: 205831_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000358489
Ensembl peptide - ENSP00000358490
NCBI entrez gene - 914     See in Manteia.
OMIM - 186990
RefSeq - NM_001767
RefSeq Peptide - NP_001758
swissprot - P06729
swissprot - Q53F96
swissprot - Q5JVN7
Ensembl - ENSG00000116824
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Cd2ENSMUSG00000027863Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008424  Immunoglobulin C2-set
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR015632  T-cell surface antigen CD2
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001766 membrane raft polarization TAS
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0030101 natural killer cell activation NAS
 biological_processGO:0030887 positive regulation of myeloid dendritic cell activation NAS
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IDA
 biological_processGO:0034113 heterotypic cell-cell adhesion IDA
 biological_processGO:0042110 T cell activation TAS
 biological_processGO:0045580 regulation of T cell differentiation NAS
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0098609 cell-cell adhesion NAS
 biological_processGO:1902715 positive regulation of interferon-gamma secretion IDA
 biological_processGO:2000484 positive regulation of interleukin-8 secretion IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0046658 anchored component of plasma membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000116815 CD58 / P19256 / CD58 molecule  / reaction / complex






 

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