ENSG00000116874


Homo sapiens

Features
Gene ID: ENSG00000116874
  
Biological name :WARS2
  
Synonyms : Q9UGM6 / tryptophanyl tRNA synthetase 2, mitochondrial / WARS2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p12
Gene start: 119031216
Gene end: 119140671
  
Corresponding Affymetrix probe sets: 1561297_at (Human Genome U133 Plus 2.0 Array)   218766_s_at (Human Genome U133 Plus 2.0 Array)   222734_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000235521
Ensembl peptide - ENSP00000358434
NCBI entrez gene - 10352     See in Manteia.
OMIM - 604733
RefSeq - XM_017000042
RefSeq - NM_015836
RefSeq - NM_201263
RefSeq - XM_017000038
RefSeq - XM_017000039
RefSeq - XM_017000040
RefSeq - XM_005270350
RefSeq - XM_011540494
RefSeq - XM_011540495
RefSeq Peptide - NP_957715
RefSeq Peptide - NP_056651
swissprot - Q9UGM6
Ensembl - ENSG00000116874
  
Related genetic diseases (OMIM): 617710 - Neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures, 617710
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wars2ENSDARG00000011801Danio rerio
 WARS2ENSGALG00000014772Gallus gallus
 Wars2ENSMUSG00000004233Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001412  Aminoacyl-tRNA synthetase, class I, conserved site
 IPR002305  Aminoacyl-tRNA synthetase, class Ic
 IPR002306  Tryptophan-tRNA ligase
 IPR014729  Rossmann-like alpha/beta/alpha sandwich fold
 IPR024109  Tryptophan-tRNA ligase, bacterial-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001570 vasculogenesis IEA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006418 tRNA aminoacylation for protein translation TAS
 biological_processGO:0006436 tryptophanyl-tRNA aminoacylation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004812 aminoacyl-tRNA ligase activity IEA
 molecular_functionGO:0004830 tryptophan-tRNA ligase activity TAS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA


Pathways (from Reactome)
Pathway description
Mitochondrial tRNA aminoacylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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