ENSG00000118702


Homo sapiens

Features
Gene ID: ENSG00000118702
  
Biological name :GHRH
  
Synonyms : GHRH / growth hormone releasing hormone / P01286
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: q11.23
Gene start: 37251082
Gene end: 37261835
  
Corresponding Affymetrix probe sets: 214524_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000237527
Ensembl peptide - ENSP00000362713
Ensembl peptide - ENSP00000362716
NCBI entrez gene - 2691     See in Manteia.
OMIM - 139190
RefSeq - XM_011528788
RefSeq - NM_001184731
RefSeq - NM_021081
RefSeq - XM_011528784
RefSeq Peptide - NP_001171660
RefSeq Peptide - NP_066567
swissprot - P01286
Ensembl - ENSG00000118702
  
Related genetic diseases (OMIM): 139190 - ?Isolated growth hormone deficiency due to defect in GHRF
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GhrhENSMUSG00000027643Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000532  Glucagon/GIP/secretin/VIP


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway ISS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0021984 adenohypophysis development ISS
 biological_processGO:0030252 growth hormone secretion IDA
 biological_processGO:0032094 response to food ISS
 biological_processGO:0040018 positive regulation of multicellular organism growth IMP
 biological_processGO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway NAS
 biological_processGO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep NAS
 biological_processGO:0046887 positive regulation of hormone secretion IEA
 biological_processGO:0060124 positive regulation of growth hormone secretion NAS
 cellular_componentGO:0005576 extracellular region NAS
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0043195 terminal bouton ISS
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0016608 growth hormone-releasing hormone activity IDA
 molecular_functionGO:0031770 growth hormone-releasing hormone receptor binding IPI


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Glucagon-type ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106128 GHRHR / Q02643 / growth hormone releasing hormone receptor  / complex / reaction






 

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