ENSMUSG00000027643


Mus musculus

Features
Gene ID: ENSMUSG00000027643
  
Biological name :Ghrh
  
Synonyms : Ghrh / Mus musculus growth hormone releasing hormone (Ghrh), transcript variant 2, mRNA. / P16043
  
Possible biological names infered from orthology : growth hormone releasing hormone / P01286
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H1
Gene start: 157329497
Gene end: 157347506
  
Corresponding Affymetrix probe sets: 10489179 (MoGene1.0st)   1419634_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029172
Ensembl peptide - ENSMUSP00000105162
NCBI entrez gene - 14601     See in Manteia.
MGI - MGI:95709
RefSeq - XM_006498773
RefSeq - NM_001329683
RefSeq - NM_010285
RefSeq - XM_006498772
RefSeq Peptide - NP_001316612
RefSeq Peptide - NP_034415
swissprot - P16043
swissprot - Q544X5
Ensembl - ENSMUSG00000027643
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GHRHENSG00000118702Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000532  Glucagon/GIP/secretin/VIP


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0021984 adenohypophysis development IMP
 biological_processGO:0030252 growth hormone secretion IEA
 biological_processGO:0032094 response to food IDA
 biological_processGO:0040018 positive regulation of multicellular organism growth IEA
 biological_processGO:0046887 positive regulation of hormone secretion IMP
 biological_processGO:0060124 positive regulation of growth hormone secretion IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0043195 terminal bouton IDA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016608 growth hormone-releasing hormone activity IEA
 molecular_functionGO:0031770 growth hormone-releasing hormone receptor binding IPI


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Glucagon-type ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-Shh)1Jaw/0
Genetic Background: involves: FVB/N

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-Shh)1Jaw/0
Genetic Background: involves: FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Shhtm1Amc/Shhtm1Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-Shh)1Jaw/0
Genetic Background: involves: FVB/N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Shhtm1Amc/Shhtm1Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-Shh)1Jaw/0
Genetic Background: involves: FVB/N

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-Shh)1Jaw/0
Genetic Background: involves: FVB/N

 MP:0002659 pituitary gland hypoplasia "decreased size of pituitary gland due to decreased cell number" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-Shh)1Jaw/0
Genetic Background: involves: FVB/N

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-Shh)1Jaw/0
Genetic Background: involves: FVB/N

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Shhtm1Amc/Shhtm1Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-Shh)1Jaw/0
Genetic Background: involves: FVB/N

 MP:0005136 decreased growth hormone level "less than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Shhtm1Amc/Shhtm1Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-Shh)1Jaw/0
Genetic Background: involves: FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004654 Ghrhr / P32082 / Growth hormone-releasing hormone receptor / Q02643*  / complex / reaction






 

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