ENSG00000119487


Homo sapiens

Features
Gene ID: ENSG00000119487
  
Biological name :MAPKAP1
  
Synonyms : MAPKAP1 / mitogen-activated protein kinase associated protein 1 / Q9BPZ7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q33.3
Gene start: 125437393
Gene end: 125707234
  
Corresponding Affymetrix probe sets: 217808_s_at (Human Genome U133 Plus 2.0 Array)   222426_at (Human Genome U133 Plus 2.0 Array)   229845_at (Human Genome U133 Plus 2.0 Array)   229846_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000377627
Ensembl peptide - ENSP00000377624
Ensembl peptide - ENSP00000390024
Ensembl peptide - ENSP00000418607
Ensembl peptide - ENSP00000417766
Ensembl peptide - ENSP00000412485
Ensembl peptide - ENSP00000408359
Ensembl peptide - ENSP00000400182
Ensembl peptide - ENSP00000265960
Ensembl peptide - ENSP00000265961
Ensembl peptide - ENSP00000362595
Ensembl peptide - ENSP00000362597
Ensembl peptide - ENSP00000362602
Ensembl peptide - ENSP00000362610
NCBI entrez gene - 79109     See in Manteia.
OMIM - 610558
RefSeq - XM_017015127
RefSeq - NM_001006617
RefSeq - NM_001006618
RefSeq - NM_001006619
RefSeq - NM_001006620
RefSeq - NM_001006621
RefSeq - NM_024117
RefSeq - XM_011519005
RefSeq - XM_011519006
RefSeq - XM_011519007
RefSeq - XM_011519008
RefSeq - XM_011519009
RefSeq - XM_011519010
RefSeq - XM_017015126
RefSeq Peptide - NP_001006620
RefSeq Peptide - NP_001006621
RefSeq Peptide - NP_001006622
RefSeq Peptide - NP_077022
RefSeq Peptide - NP_001006619
RefSeq Peptide - NP_001006618
swissprot - H0Y7F8
swissprot - H0Y866
swissprot - Q9BPZ7
swissprot - A0A024R863
swissprot - E9PGB8
swissprot - B1AMB2
swissprot - B1AMB1
swissprot - B1AMA6
swissprot - B1AMA5
Ensembl - ENSG00000119487
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapkap1ENSDARG00000091777Danio rerio
 Q9W6S3ENSGALG00000000977Gallus gallus
 Q8BKH7ENSMUSG00000038696Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR031313  SAPK-interacting protein 1, Pleckstrin-homology domain
 IPR031567  Sin1, middle CRIM domain
 IPR032679  Sin1, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0021762 substantia nigra development HEP
 biological_processGO:0030950 establishment or maintenance of actin cytoskeleton polarity IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032148 activation of protein kinase B activity TAS
 biological_processGO:0038203 TORC2 signaling IBA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031932 TORC2 complex IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0017016 Ras GTPase binding IDA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0043325 phosphatidylinositol-3,4-bisphosphate binding IDA
 molecular_functionGO:0070300 phosphatidic acid binding IDA
 molecular_functionGO:0080025 phosphatidylinositol-3,5-bisphosphate binding IDA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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