ENSG00000120949


Homo sapiens

Features
Gene ID: ENSG00000120949
  
Biological name :TNFRSF8
  
Synonyms : P28908 / TNF receptor superfamily member 8 / TNFRSF8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.22
Gene start: 12063377
Gene end: 12144207
  
Corresponding Affymetrix probe sets: 206729_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000421938
Ensembl peptide - ENSP00000263932
Ensembl peptide - ENSP00000390650
Ensembl peptide - ENSP00000398337
NCBI entrez gene - 943     See in Manteia.
OMIM - 153243
RefSeq - XM_011542443
RefSeq - NM_001243
RefSeq - NM_001281430
RefSeq - XM_011542441
RefSeq Peptide - NP_001268359
RefSeq Peptide - NP_001234
swissprot - P28908
swissprot - D6RAG8
Ensembl - ENSG00000120949
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TNFRSF8ENSGALG00000039741Gallus gallus
 Q60846ENSMUSG00000028602Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR020416  Tumour necrosis factor receptor 8
 IPR034002  Tumour necrosis factor receptor 8, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007411 axon guidance IBA
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0010977 negative regulation of neuron projection development IBA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0042535 positive regulation of tumor necrosis factor biosynthetic process IDA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0045556 positive regulation of TRAIL biosynthetic process IDA
 biological_processGO:0071260 cellular response to mechanical stimulus IEP
 biological_processGO:0097190 apoptotic signaling pathway IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043005 neuron projection IBA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004888 transmembrane signaling receptor activity TAS
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0048406 nerve growth factor binding IBA


Pathways (from Reactome)
Pathway description
TNFs bind their physiological receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106952 P32971 / TNFSF8 / TNF superfamily member 8  / reaction / complex






 

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