ENSG00000106952


Homo sapiens

Features
Gene ID: ENSG00000106952
  
Biological name :TNFSF8
  
Synonyms : P32971 / TNFSF8 / TNF superfamily member 8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q33.1
Gene start: 114893343
Gene end: 114930595
  
Corresponding Affymetrix probe sets: 207216_at (Human Genome U133 Plus 2.0 Array)   235735_at (Human Genome U133 Plus 2.0 Array)   241819_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000484651
Ensembl peptide - ENSP00000223795
NCBI entrez gene - 944     See in Manteia.
OMIM - 603875
RefSeq - NM_001244
RefSeq - NM_001252290
RefSeq Peptide - NP_001235
RefSeq Peptide - NP_001239219
swissprot - Q52M88
swissprot - P32971
swissprot - A0A087X228
Ensembl - ENSG00000106952
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TNFSF8ENSGALG00000007121Gallus gallus
 P32972ENSMUSG00000028362Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006052  Tumour necrosis factor domain
 IPR008983  Tumour necrosis factor-like domain superfamily
 IPR021184  Tumour necrosis factor, conserved site
 IPR021185  Tumour necrosis factor family protein, CD30 ligand type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0043374 CD8-positive, alpha-beta T cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
TNFs bind their physiological receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000120949 P28908 / TNFRSF8 / TNF receptor superfamily member 8  / reaction / complex






 

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