ENSMUSG00000028362


Mus musculus

Features
Gene ID: ENSMUSG00000028362
  
Biological name :Tnfsf8
  
Synonyms : P32972 / Tnfsf8 / tumor necrosis factor (ligand) superfamily, member 8
  
Possible biological names infered from orthology : P32971 / TNF superfamily member 8
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C1
Gene start: 63831308
Gene end: 63861347
  
Corresponding Affymetrix probe sets: 10513729 (MoGene1.0st)   1450272_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030047
NCBI entrez gene - 21949     See in Manteia.
MGI - MGI:88328
RefSeq - XM_017320114
RefSeq - NM_009403
RefSeq Peptide - NP_033429
swissprot - P32972
swissprot - Q544U1
Ensembl - ENSMUSG00000028362
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TNFSF8ENSGALG00000007121Gallus gallus
 P32971ENSG00000106952Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006052  Tumour necrosis factor domain
 IPR008983  Tumour necrosis factor-like domain superfamily
 IPR021184  Tumour necrosis factor, conserved site
 IPR021185  Tumour necrosis factor family protein, CD30 ligand type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0043374 CD8-positive, alpha-beta T cell differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0050830 defense response to Gram-positive bacterium IMP
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
TNFs bind their physiological receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005673 decreased susceptibility to graft versus host disease "less likelihood of developing clinical symptoms of anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the a graft versus host reaction, which is an immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
Show

Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028602 Q60846 / Tnfrsf8 / Tumor necrosis factor receptor superfamily member 8 / P28908* / TNF receptor superfamily member 8*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr