ENSG00000123415


Homo sapiens

Features
Gene ID: ENSG00000123415
  
Biological name :SMUG1
  
Synonyms : Q53HV7 / single-strand-selective monofunctional uracil-DNA glycosylase 1 / SMUG1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.13
Gene start: 54121277
Gene end: 54189008
  
Corresponding Affymetrix probe sets: 218685_s_at (Human Genome U133 Plus 2.0 Array)   223684_s_at (Human Genome U133 Plus 2.0 Array)   234708_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000421790
Ensembl peptide - ENSP00000421206
Ensembl peptide - ENSP00000421894
Ensembl peptide - ENSP00000489489
Ensembl peptide - ENSP00000427547
Ensembl peptide - ENSP00000426440
Ensembl peptide - ENSP00000425974
Ensembl peptide - ENSP00000425426
Ensembl peptide - ENSP00000424191
Ensembl peptide - ENSP00000423629
Ensembl peptide - ENSP00000423457
Ensembl peptide - ENSP00000423083
Ensembl peptide - ENSP00000243112
Ensembl peptide - ENSP00000338606
Ensembl peptide - ENSP00000384828
Ensembl peptide - ENSP00000421139
NCBI entrez gene - 23583     See in Manteia.
OMIM - 607753
RefSeq - XM_017019120
RefSeq - NM_001243787
RefSeq - NM_001243788
RefSeq - NM_001243789
RefSeq - NM_001243790
RefSeq - NM_001243791
RefSeq - NM_001351237
RefSeq - NM_014311
RefSeq - XM_006719319
RefSeq - XM_006719320
RefSeq - XM_006719321
RefSeq - XM_006719322
RefSeq - XM_011538109
RefSeq - XM_011538110
RefSeq - XM_011538111
RefSeq - XM_011538112
RefSeq - XM_011538113
RefSeq - XM_011538114
RefSeq - XM_011538115
RefSeq - XM_011538116
RefSeq - XM_011538117
RefSeq - XM_011538118
RefSeq - XM_011538119
RefSeq - XM_011538120
RefSeq - XM_011538121
RefSeq - XM_011538122
RefSeq - XM_011538123
RefSeq - XM_017019113
RefSeq - XM_017019114
RefSeq - XM_017019115
RefSeq - XM_017019116
RefSeq - XM_017019117
RefSeq - XM_017019118
RefSeq - XM_017019119
RefSeq Peptide - NP_001338176
RefSeq Peptide - NP_001338178
RefSeq Peptide - NP_001338179
RefSeq Peptide - NP_001338180
RefSeq Peptide - NP_001338181
RefSeq Peptide - NP_001338182
RefSeq Peptide - NP_001338183
RefSeq Peptide - NP_001230720
RefSeq Peptide - NP_001338166
RefSeq Peptide - NP_001338167
RefSeq Peptide - NP_001338168
RefSeq Peptide - NP_001338169
RefSeq Peptide - NP_001338170
RefSeq Peptide - NP_001338171
RefSeq Peptide - NP_001338172
RefSeq Peptide - NP_001338173
RefSeq Peptide - NP_001338174
RefSeq Peptide - NP_001338175
RefSeq Peptide - NP_001338177
RefSeq Peptide - NP_001338184
RefSeq Peptide - NP_001338185
RefSeq Peptide - NP_001338186
RefSeq Peptide - NP_001338191
RefSeq Peptide - NP_055126
RefSeq Peptide - NP_001230716
RefSeq Peptide - NP_001230717
RefSeq Peptide - NP_001230718
RefSeq Peptide - NP_001230719
swissprot - D6RIA4
swissprot - D6RI04
swissprot - D6RD88
swissprot - D6RAS0
swissprot - D6RAI1
swissprot - D6RA78
swissprot - D6RA25
swissprot - A0A0U1RRE6
swissprot - A0A0S2Z526
swissprot - H0YA95
swissprot - A0A024RAZ8
swissprot - Q53HV7
Ensembl - ENSG00000123415
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smug1ENSDARG00000101308Danio rerio
 SMUG1ENSGALG00000031601Gallus gallus
 Smug1ENSMUSG00000036061Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR036895  Uracil-DNA glycosylase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0045008 depyrimidination TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 molecular_functionGO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004844 uracil DNA N-glycosylase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017065 single-strand selective uracil DNA N-glycosylase activity TAS
 molecular_functionGO:0019104 DNA N-glycosylase activity IDA


Pathways (from Reactome)
Pathway description
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Displacement of DNA glycosylase by APEX1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100823 APEX1 / P27695 / apurinic/apyrimidinic endodeoxyribonuclease 1  / reaction






 

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