ENSMUSG00000036061


Mus musculus

Features
Gene ID: ENSMUSG00000036061
  
Biological name :Smug1
  
Synonyms : Q6P5C5 / Single-strand selective monofunctional uracil DNA glycosylase / Smug1
  
Possible biological names infered from orthology : Q53HV7 / single-strand-selective monofunctional uracil-DNA glycosylase 1
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F3
Gene start: 103153290
Gene end: 103167092
  
Corresponding Affymetrix probe sets: 10433077 (MoGene1.0st)   1428763_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000065835
Ensembl peptide - ENSMUSP00000155293
Ensembl peptide - ENSMUSP00000155594
Ensembl peptide - ENSMUSP00000155700
NCBI entrez gene - 71726     See in Manteia.
MGI - MGI:1918976
RefSeq - XM_017316752
RefSeq - NM_027885
RefSeq - XM_011245732
RefSeq - XM_011245733
RefSeq - XM_006521415
RefSeq - XM_011245731
RefSeq Peptide - NP_082161
swissprot - Q6P5C5
Ensembl - ENSMUSG00000036061
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smug1ENSDARG00000101308Danio rerio
 SMUG1ENSGALG00000031601Gallus gallus
 SMUG1ENSG00000123415Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR036895  Uracil-DNA glycosylase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair ISA
 biological_processGO:0006284 base-excision repair ISS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0031981 nuclear lumen IBA
 molecular_functionGO:0000702 oxidized base lesion DNA N-glycosylase activity ISA
 molecular_functionGO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding ISA
 molecular_functionGO:0004844 uracil DNA N-glycosylase activity ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017065 single-strand selective uracil DNA N-glycosylase activity ISS
 molecular_functionGO:0019104 DNA N-glycosylase activity ISS


Pathways (from Reactome)
Pathway description
Cleavage of the damaged pyrimidine
Displacement of DNA glycosylase by APEX1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu,Ungtm1Tld/Ungtm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu,Ungtm1Tld/Ungtm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: P4hbtm1.1Geno/P4hbtm1.2Geno,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0009796 abnormal base-excision repair "any anomaly in the process whereby an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate; the small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase" [GO:0006284]
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Allelic Composition: P4hbtm1.1Geno/P4hbtm1.2Geno,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu,Ungtm1Tld/Ungtm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

Allelic Composition: Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0009797 abnormal mismatch repair "any functional anomaly in the system that promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination" [GO:0006298]
Show

Allelic Composition: Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu,Ungtm1Tld/Ungtm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu,Ungtm1Tld/Ungtm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu,Ungtm1Tld/Ungtm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000035960 Apex1 / P28352 / DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) lyase, mitochondrial / P27695* / apurinic/apyrimidinic endodeoxyribonuclease 1*  / reaction






 

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