ENSG00000124795


Homo sapiens

Features
Gene ID: ENSG00000124795
  
Biological name :DEK
  
Synonyms : DEK / DEK proto-oncogene / P35659
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p22.3
Gene start: 18223868
Gene end: 18264823
  
Corresponding Affymetrix probe sets: 200934_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000421165
Ensembl peptide - ENSP00000422380
Ensembl peptide - ENSP00000425399
Ensembl peptide - ENSP00000423553
Ensembl peptide - ENSP00000423427
Ensembl peptide - ENSP00000244776
Ensembl peptide - ENSP00000380414
NCBI entrez gene - 7913     See in Manteia.
OMIM - 125264
RefSeq - XM_017011273
RefSeq - NM_001134709
RefSeq - NM_003472
RefSeq Peptide - NP_001128181
RefSeq Peptide - NP_003463
swissprot - P35659
swissprot - D6RDA2
swissprot - D6R9L5
swissprot - H0Y8X0
swissprot - B4DFG0
swissprot - H0Y993
Ensembl - ENSG00000124795
  
Related genetic diseases (OMIM): 125264 - Leukemia, acute nonlymphocytic
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dekENSDARG00000070108Danio rerio
 DEKENSGALG00000012684Gallus gallus
 DekENSMUSG00000021377Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003034  SAP domain
 IPR014876  DEK, C-terminal
 IPR036361  SAP domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006338 chromatin remodeling IBA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0019079 viral genome replication TAS
 biological_processGO:0045815 positive regulation of gene expression, epigenetic TAS
 biological_processGO:2000779 regulation of double-strand break repair IMP
 biological_processGO:2001032 regulation of double-strand break repair via nonhomologous end joining IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0043292 contractile fiber IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0042393 histone binding IDA


Pathways (from Reactome)
Pathway description
B-WICH complex positively regulates rRNA expression
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000137203 P05549 / TFAP2A / transcription factor AP-2 alpha  / reaction / complex






 

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