ENSG00000125107


Homo sapiens

Features
Gene ID: ENSG00000125107
  
Biological name :CNOT1
  
Synonyms : A5YKK6 / CCR4-NOT transcription complex subunit 1 / CNOT1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: q21
Gene start: 58519951
Gene end: 58629886
  
Corresponding Affymetrix probe sets: 1554052_at (Human Genome U133 Plus 2.0 Array)   200860_s_at (Human Genome U133 Plus 2.0 Array)   200861_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000457869
Ensembl peptide - ENSP00000485782
Ensembl peptide - ENSP00000458057
Ensembl peptide - ENSP00000320949
Ensembl peptide - ENSP00000413113
Ensembl peptide - ENSP00000454377
Ensembl peptide - ENSP00000454611
Ensembl peptide - ENSP00000454763
Ensembl peptide - ENSP00000455289
Ensembl peptide - ENSP00000455635
Ensembl peptide - ENSP00000456131
Ensembl peptide - ENSP00000456649
Ensembl peptide - ENSP00000456975
Ensembl peptide - ENSP00000457173
Ensembl peptide - ENSP00000457460
NCBI entrez gene - 23019     See in Manteia.
OMIM - 604917
RefSeq - NM_001265612
RefSeq - NM_016284
RefSeq - NM_206999
RefSeq Peptide - NP_001252541
RefSeq Peptide - NP_057368
RefSeq Peptide - NP_996882
swissprot - A5YKK6
swissprot - H3BU44
swissprot - H3BVC9
swissprot - H3BTH2
swissprot - H3BMH0
swissprot - H3BMZ2
swissprot - H3BNB1
swissprot - H3BPF1
swissprot - H3BR89
swissprot - H3BT18
Ensembl - ENSG00000125107
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnot1ENSDARG00000004174Danio rerio
 CNOT1ENSGALG00000002301Gallus gallus
 Cnot1ENSMUSG00000036550Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007196  CCR4-Not complex component, Not1, C-terminal
 IPR011989  Armadillo-like helical
 IPR024557  CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819
 IPR032191  CCR4-NOT transcription complex subunit 1, CAF1-binding domain
 IPR032193  CCR4-NOT transcription complex subunit 1, TTP binding domain
 IPR032194  CCR4-NOT transcription complex subunit 1, HEAT repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010606 positive regulation of cytoplasmic mRNA processing body assembly IDA
 biological_processGO:0017148 negative regulation of translation IDA
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0033147 negative regulation of intracellular estrogen receptor signaling pathway IDA
 biological_processGO:0035195 gene silencing by miRNA IDA
 biological_processGO:0048387 negative regulation of retinoic acid receptor signaling pathway IDA
 biological_processGO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IDA
 biological_processGO:0061014 positive regulation of mRNA catabolic process IMP
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 biological_processGO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
 biological_processGO:2000036 regulation of stem cell population maintenance IMP
 cellular_componentGO:0000932 P-body ISS
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0030014 CCR4-NOT complex IDA
 cellular_componentGO:0030015 CCR4-NOT core complex IBA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004535 poly(A)-specific ribonuclease activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0030331 estrogen receptor binding IDA
 molecular_functionGO:0032947 protein-containing complex scaffold activity IDA
 molecular_functionGO:0042974 retinoic acid receptor binding IDA
 molecular_functionGO:0070016 armadillo repeat domain binding IPI


Pathways (from Reactome)
Pathway description
Deadenylation of mRNA
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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