ENSMUSG00000036550


Mus musculus

Features
Gene ID: ENSMUSG00000036550
  
Biological name :Cnot1
  
Synonyms : CCR4-NOT transcription complex subunit 1 / Cnot1 / Q6ZQ08
  
Possible biological names infered from orthology : A5YKK6
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: D1
Gene start: 95719451
Gene end: 95807464
  
Corresponding Affymetrix probe sets: 10413161 (MoGene1.0st)   10580905 (MoGene1.0st)   10580953 (MoGene1.0st)   1434251_at (Mouse Genome 430 2.0 Array)   1457546_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000063565
Ensembl peptide - ENSMUSP00000148831
Ensembl peptide - ENSMUSP00000148807
Ensembl peptide - ENSMUSP00000148735
Ensembl peptide - ENSMUSP00000148709
Ensembl peptide - ENSMUSP00000148575
Ensembl peptide - ENSMUSP00000148574
Ensembl peptide - ENSMUSP00000096073
NCBI entrez gene - 234594     See in Manteia.
MGI - MGI:2442402
RefSeq - XM_017312735
RefSeq - NM_001205226
RefSeq - NM_153164
RefSeq - NM_178078
RefSeq - XM_006530870
RefSeq - XM_006530871
RefSeq - XM_006530872
RefSeq - XM_006530874
RefSeq Peptide - NP_001192155
RefSeq Peptide - NP_694804
RefSeq Peptide - NP_835179
swissprot - Q6ZQ08
swissprot - A0A1D5RMB6
swissprot - A0A1D5RM04
swissprot - A0A1D5RM03
swissprot - A0A1D5RML9
swissprot - A0A1D5RMD8
swissprot - B7ZWL1
swissprot - A0A1D5RMJ8
Ensembl - ENSMUSG00000036550
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnot1ENSDARG00000004174Danio rerio
 CNOT1ENSGALG00000002301Gallus gallus
 CNOT1ENSG00000125107Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007196  CCR4-Not complex component, Not1, C-terminal
 IPR024557  CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819
 IPR032191  CCR4-NOT transcription complex subunit 1, CAF1-binding domain
 IPR032193  CCR4-NOT transcription complex subunit 1, TTP binding domain
 IPR032194  CCR4-NOT transcription complex subunit 1, HEAT repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
 biological_processGO:0001829 trophectodermal cell differentiation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010606 positive regulation of cytoplasmic mRNA processing body assembly ISO
 biological_processGO:0017148 negative regulation of translation IBA
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0033147 negative regulation of intracellular estrogen receptor signaling pathway ISS
 biological_processGO:0035195 gene silencing by miRNA ISO
 biological_processGO:0048387 negative regulation of retinoic acid receptor signaling pathway ISS
 biological_processGO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
 biological_processGO:0061014 positive regulation of mRNA catabolic process ISO
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 biological_processGO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISS
 biological_processGO:2000036 regulation of stem cell population maintenance IMP
 cellular_componentGO:0000932 P-body ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0030014 CCR4-NOT complex ISO
 cellular_componentGO:0030015 CCR4-NOT core complex IBA
 molecular_functionGO:0004535 poly(A)-specific ribonuclease activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0030331 estrogen receptor binding ISS
 molecular_functionGO:0032947 protein-containing complex scaffold activity IBA
 molecular_functionGO:0042974 retinoic acid receptor binding ISS
 molecular_functionGO:0070016 armadillo repeat domain binding ISO


Pathways (from Reactome)
Pathway description
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003233 prolonged QT interval "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Cnot1tm1Tya/Cnot1tm1Tya,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB

 MP:0010632 cardiac muscle necrosis "pathological death of cardiomyocytes or a portion of the cardiac muscle tissue; usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Cnot1tm1Tya/Cnot1tm1Tya,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Cnot1tm1Tya/Cnot1tm1Tya,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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