ENSG00000127311


Homo sapiens

Features
Gene ID: ENSG00000127311
  
Biological name :HELB
  
Synonyms : DNA helicase B / HELB / Q8NG08
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q14.3
Gene start: 66302545
Gene end: 66347645
  
Corresponding Affymetrix probe sets: 1552787_at (Human Genome U133 Plus 2.0 Array)   1552788_a_at (Human Genome U133 Plus 2.0 Array)   1570200_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000247815
Ensembl peptide - ENSP00000396955
Ensembl peptide - ENSP00000439617
Ensembl peptide - ENSP00000443287
NCBI entrez gene - 92797     See in Manteia.
OMIM - 614539
RefSeq - XM_017020230
RefSeq - NM_033647
RefSeq - XM_005269234
RefSeq Peptide - NP_387467
swissprot - Q8NG08
swissprot - F5H1I4
Ensembl - ENSG00000127311
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 helbENSDARG00000053127Danio rerio
 HELBENSGALG00000009885Gallus gallus
 HelbENSMUSG00000020228Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR027044  DNA helicase B
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027785  UvrD-like helicase C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IMP
 biological_processGO:0006261 DNA-dependent DNA replication IEA
 biological_processGO:0006269 DNA replication, synthesis of RNA primer IDA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006396 RNA processing IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:1903775 regulation of DNA double-strand break processing IMP
 biological_processGO:2000042 negative regulation of double-strand break repair via homologous recombination IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005658 alpha DNA polymerase:primase complex IDA
 cellular_componentGO:0005662 DNA replication factor A complex IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0035861 site of double-strand break IMP
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding IBA
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity IDA
 molecular_functionGO:0043141 ATP-dependent 5"-3" DNA helicase activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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