ENSMUSG00000020228


Mus musculus

Features
Gene ID: ENSMUSG00000020228
  
Biological name :Helb
  
Synonyms : DNA helicase B / Helb / Q6NVF4
  
Possible biological names infered from orthology : Q8NG08
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D2
Gene start: 120083608
Gene end: 120112987
  
Corresponding Affymetrix probe sets: 10372766 (MoGene1.0st)   1419234_at (Mouse Genome 430 2.0 Array)   1419235_s_at (Mouse Genome 430 2.0 Array)   1419236_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116954
Ensembl peptide - ENSMUSP00000020449
NCBI entrez gene - 117599     See in Manteia.
MGI - MGI:2152895
RefSeq - NM_080446
RefSeq - XM_017313781
RefSeq Peptide - NP_536694
swissprot - D6RGT6
swissprot - Q6NVF4
Ensembl - ENSMUSG00000020228
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 helbENSDARG00000053127Danio rerio
 HELBENSGALG00000009885Gallus gallus
 HELBENSG00000127311Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR027044  DNA helicase B
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027785  UvrD-like helicase C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006261 DNA-dependent DNA replication IEA
 biological_processGO:0006269 DNA replication, synthesis of RNA primer IEA
 biological_processGO:0006396 RNA processing IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:1903775 regulation of DNA double-strand break processing IMP
 biological_processGO:2000042 negative regulation of double-strand break repair via homologous recombination IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005658 alpha DNA polymerase:primase complex IEA
 cellular_componentGO:0005662 DNA replication factor A complex IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0035861 site of double-strand break IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding IBA
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity IEA
 molecular_functionGO:0043141 ATP-dependent 5"-3" DNA helicase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
Show

Allelic Composition: Il6sttm1Ern/Il6sttm1Ern,Tg(RP11-H2112)9Trme/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * DBA/2J

Allelic Composition: Helbtm1(KOMP)Vlcg/Helbtm1(KOMP)Vlcg,Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic Background: involves: 129 * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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