ENSG00000127954


Homo sapiens

Features
Gene ID: ENSG00000127954
  
Biological name :STEAP4
  
Synonyms : Q687X5 / STEAP4 / STEAP4 metalloreductase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q21.12
Gene start: 88270892
Gene end: 88306891
  
Corresponding Affymetrix probe sets: 1556185_a_at (Human Genome U133 Plus 2.0 Array)   220187_at (Human Genome U133 Plus 2.0 Array)   225987_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000394399
Ensembl peptide - ENSP00000305545
Ensembl peptide - ENSP00000369419
NCBI entrez gene - 79689     See in Manteia.
OMIM - 611098
RefSeq - NM_001205315
RefSeq - NM_001205316
RefSeq - NM_024636
RefSeq Peptide - NP_001192244
RefSeq Peptide - NP_001192245
RefSeq Peptide - NP_078912
swissprot - Q687X5
swissprot - C9JS50
Ensembl - ENSG00000127954
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 steap4ENSDARG00000055901Danio rerio
 STEAP4ENSGALG00000008997Gallus gallus
 Q923B6ENSMUSG00000012428Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8NFT2 / STEAP2 / STEAP2 metalloreductaseENSG0000015721446
Q658P3 / STEAP3 / STEAP3 metalloreductaseENSG0000011510745
Q9UHE8 / STEAP1 / STEAP family member 1ENSG0000016464724
Q6NZ63 / STEAP1B / STEAP family member 1BENSG0000010588920


Protein motifs (from Interpro)
Interpro ID Name
 IPR013130  Ferric reductase transmembrane component-like domain
 IPR028939  Pyrroline-5-carboxylate reductase, catalytic, N-terminal
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0015677 copper ion import IBA
 biological_processGO:0045444 fat cell differentiation ISS
 biological_processGO:0055072 iron ion homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098706 ferric iron import across plasma membrane IBA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005768 endosome IBA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0008823 cupric reductase activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0052851 ferric-chelate reductase (NADPH) activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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