ENSG00000157214


Homo sapiens

Features
Gene ID: ENSG00000157214
  
Biological name :STEAP2
  
Synonyms : Q8NFT2 / STEAP2 / STEAP2 metalloreductase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q21.13
Gene start: 90167590
Gene end: 90238137
  
Corresponding Affymetrix probe sets: 225871_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000378128
Ensembl peptide - ENSP00000378125
Ensembl peptide - ENSP00000384191
Ensembl peptide - ENSP00000415931
Ensembl peptide - ENSP00000401783
Ensembl peptide - ENSP00000287908
Ensembl peptide - ENSP00000378119
Ensembl peptide - ENSP00000378120
Ensembl peptide - ENSP00000378123
NCBI entrez gene - 261729     See in Manteia.
OMIM - 605094
RefSeq - XM_017011958
RefSeq - NM_001040666
RefSeq - NM_001244944
RefSeq - NM_001244945
RefSeq - NM_001244946
RefSeq - NM_152999
RefSeq - XM_006715921
RefSeq - XM_017011953
RefSeq - XM_017011954
RefSeq - XM_017011955
RefSeq - XM_017011956
RefSeq - XM_017011957
RefSeq - NM_001040665
RefSeq Peptide - NP_001231875
RefSeq Peptide - NP_694544
RefSeq Peptide - NP_001035755
RefSeq Peptide - NP_001035756
RefSeq Peptide - NP_001231873
RefSeq Peptide - NP_001231874
swissprot - Q6YPB2
swissprot - C9JHX5
swissprot - C9JLP2
swissprot - Q8NFT2
swissprot - B5MC02
Ensembl - ENSG00000157214
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 steap2ENSDARG00000062887Danio rerio
 STEAP2ENSGALG00000009017Gallus gallus
 Q8BWB6ENSMUSG00000015653Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q658P3 / STEAP3 / STEAP3 metalloreductaseENSG0000011510752
Q687X5 / STEAP4 / STEAP4 metalloreductaseENSG0000012795443
Q9UHE8 / STEAP1 / STEAP family member 1ENSG0000016464731
Q6NZ63 / STEAP1B / STEAP family member 1BENSG0000010588927


Protein motifs (from Interpro)
Interpro ID Name
 IPR013130  Ferric reductase transmembrane component-like domain
 IPR028939  Pyrroline-5-carboxylate reductase, catalytic, N-terminal
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006893 Golgi to plasma membrane transport IDA
 biological_processGO:0006897 endocytosis IDA
 biological_processGO:0009725 response to hormone IDA
 biological_processGO:0015677 copper ion import IEA
 biological_processGO:0045055 regulated exocytosis IDA
 biological_processGO:0055072 iron ion homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098706 ferric iron import across plasma membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030140 trans-Golgi network transport vesicle IDA
 cellular_componentGO:0030173 integral component of Golgi membrane IDA
 molecular_functionGO:0005215 transporter activity IDA
 molecular_functionGO:0008823 cupric reductase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0052851 ferric-chelate reductase (NADPH) activity IEA


Pathways (from Reactome)
Pathway description
Transferrin endocytosis and recycling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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